Thursday, January 31, 2013

Hagel: Window closing on Iran and diplomacy

WASHINGTON (AP) ? Defense Secretary nominee Chuck Hagel said the "window is closing" on Iran and the possibility of diplomacy if it continues to ignore international demands to end pursuit of a nuclear weapon.

In his first opportunity to express his opinions since President Barack Obama nominated him Jan. 7, Hagel addressed a range of issues, from Iraq and Afghanistan to women in combat, in a 112-page questionnaire for the Senate Armed Services Committee. The panel submitted the extensive questions to Hagel in advance of his confirmation hearing on Thursday.

The former two-term Republican senator has faced a barrage of criticism that he is not sufficiently pro-Israel and tough on Iran. In his responses, Hagel adopted a hardline on Iran, echoing Obama's contention that the United States would consider all options, including military action, to keep Iran from acquiring a nuclear weapon.

"If confirmed, I will focus intently on ensuring that U.S. military is in fact prepared for any contingency," Hagel said in response to committee questions.

The United States and other Western nations have demanded that Iran stopped its uranium-enrichment program, which they perceive as a precursor to production of nuclear warhead-grade material. Iran insists that its program is for peaceful purposes.

The most recent round of negotiations ended in a stalemate last June.

"If Iran continues to flout its international obligations, it should continue to face severe and growing consequences," Hagel said. "While there is time and space for diplomacy, backed by pressure, the window is closing. Iran needs to demonstrate it is prepared to negotiate seriously."

In the past, Hagel has questioned the efficacy of unilateral sanctions on Iran, arguing that penalties in conjunction with international partners made more sense.

He said in his response to the committee that he would continue to implement the "smart, unprecedented and effective sanctions against the Iranian regime" that Congress and the Obama administration have adopted in recent years.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-01-30-Hagel-Iran/id-c80f755396074a5893bb1c7912255e36

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Club to punish fans who racially abused Altidore

THE HAGUE, Netherlands (AP) ? The Dutch club Den Bosch pledged Wednesday to do all it can to identify and punish a group of fans who racially abused American forward Jozy Altidore during a game.

Den Bosch said fans responsible for the monkey chants Tuesday during the Dutch Cup match against Altidore's AZ Alkmaar "do not belong in the De Vliert (Stadium) and will face the toughest possible sanctions."

The racist chants gave a hollow ring to the slogan "Without respect, no football" that was coined by Dutch soccer authorities in the aftermath of the death of a linesman who was attacked by players after a match between two youth teams near Amsterdam in December.

Altidore, who is black, was not available for comment Wednesday. After the match, he told Dutch television the chants were the worst abuse he has been subjected to on a soccer field.

"It's a bit disappointing that these things still happen in this time that we're in," Altidore told Eredivisie Live. "But what you going to do? You just hope these people can find a way to improve themselves. You can only pray for them."

Altidore converted a penalty kick in his team's 5-0 win over Den Bosch, giving him a career-high 20 goals this season. He urged the referee not to take the players off the field despite the chants.

The 23-year-old, who has 13 goals in 51 appearances for the U.S. national team, said education is the key to stamping out such chants.

"At the end of the day it's still alive, racism. All we can do now is try to educate ourselves, the young kids coming up, to be better than that," Altidore said.

Den Bosch condemned the chants from a small section of the crowd.

"A cup tie that was supposed to be played in an atmosphere of respect has left us scarred," the club said in a statement on its website.

Referee Reinold Wiedemeijer halted play briefly in the second half because fans threw balls of ice at his linesmen.

Offensive chants are nothing new in Dutch soccer stadiums, but it had been hoped that the sharpened focus on respect following the death of volunteer linesman Richard Nieuwenhuizen might help eradicate them.

"(The fans) totally ruined weeks of preparations with monkey chants, throwing things at match officials and not showing respect for those on and around the pitch," Den Bosch said.

Source: http://news.yahoo.com/club-punish-fans-racially-abused-altidore-141937769--sow.html

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High-tech cargo airship being built in California

The Aeroscraft airship, a high-tech prototype airship, is seen in a World War II-era hangar in Tustin, Calif., Thursday, Jan. 24, 2013. Work is almost done on a 230-foot rigid airship inside a blimp hangar at a former military base in Orange Co. The huge cargo-carrying airship is has shiny aluminum skin and a rigid, 230-foot aluminum and carbon fiber skeleton. (AP Photo/Jae C. Hong)

The Aeroscraft airship, a high-tech prototype airship, is seen in a World War II-era hangar in Tustin, Calif., Thursday, Jan. 24, 2013. Work is almost done on a 230-foot rigid airship inside a blimp hangar at a former military base in Orange Co. The huge cargo-carrying airship is has shiny aluminum skin and a rigid, 230-foot aluminum and carbon fiber skeleton. (AP Photo/Jae C. Hong)

Leonel Cruz pulls down the flab on the Aeroscraft airship, a high-tech prototype airship, in a World War II-era hangar in Tustin, Calif., Thursday, Jan. 24, 2013. Work is almost done on a 230-foot rigid airship inside a blimp hangar at a former military base in Orange Co. The huge cargo-carrying airship is has shiny aluminum skin and a rigid, 230-foot aluminum and carbon fiber skeleton. (AP Photo/Jae C. Hong)

The Aeroscraft airship, a high-tech prototype airship, is seen in a World War II-era hangar in Tustin, Calif., Thursday, Jan. 24, 2013. Work is almost done on a 230-foot rigid airship inside a blimp hangar at a former military base in Orange Co. The huge cargo-carrying airship is has shiny aluminum skin and a rigid, 230-foot aluminum and carbon fiber skeleton. (AP Photo/Jae C. Hong)

Bradley Hasemeyer, the host of AOL's Trasnlogic show, uses his smartphone to photograph the Aeroscraft airship, a high-tech prototype airship, outside a World War II-era hangar in Tustin, Calif., Thursday, Jan. 24, 2013. Work is almost done on a 230-foot rigid airship inside the blimp hangar at a former military base in Orange Co. The huge cargo-carrying airship is has shiny aluminum skin and a rigid, 230-foot aluminum and carbon fiber skeleton. (AP Photo/Jae C. Hong)

The Aeroscraft airship, a high-tech prototype airship, is seen in a World War II-era hangar in Tustin, Calif., Thursday, Jan. 24, 2013. Work is almost done on a 230-foot rigid airship inside a blimp hangar at a former military base in Orange Co. The huge cargo-carrying airship is has shiny aluminum skin and a rigid, 230-foot aluminum and carbon fiber skeleton. (AP Photo/Jae C. Hong)

(AP) ? The massive blimp-like aircraft flies but just barely, hovering only a dozen feet off a military hangar floor during flight testing south of Los Angeles.

Still, the fact that the hulking Aeroscraft could fly for just a few minutes represents a step forward in aviation, according to the engineers who developed it. The Department of Defense and NASA have invested $35 million in the prototype because of its potential to one day carry more cargo than any other aircraft to disaster zones and forward military bases.

"I realized that I put a little dot in the line of aviation history. A little dot for something that has never been demonstrated before, now it's feasible," said flight control engineer Munir Jojo-Verge.

The airship is undergoing testing this month at Marine Corps Air Station in Tustin, and must go through several more rounds of flight testing before it could be used in a disaster zone or anywhere else. The first major flight test took place Jan. 3.

The biggest challenge for engineers is making sure the airship will be able to withstand high winds and other extreme weather conditions, Jojo-Verge said.

Worldwide Aeros, the company that developed the aircraft, said it also must secure more funding for the next round of flight testing, but is hopeful the Defense Department and others will step in again as investors.

The company says the cargo airship's potential to carry more cargo more efficiently than ever before would provide the U.S. military with an advantage on the battlefield and greater capacity to save more lives during natural disasters.

The lighter-than-air vehicle is not a blimp or a zeppelin because it has a rigid structure made out of ultra-light carbon fiber and aluminum underneath its high-tech Mylar skin. Inside, balloons hold the helium that gives the vehicle lift. Unlike hydrogen, the gas used in the Hindenburg airship that crashed in 1937, helium is not flammable.

The airship functions like a submarine, releasing air to rise and taking in air to descend, said Aeros mechanical engineer Tim Kenny. It can take off vertically, like a helicopter, then change its buoyancy to become heavier than air for landing and unloading.

"It allows the vehicle to set down on the ground. And then when we want to become lighter than air, we release that air and then the vehicle floats and we can allow it to take off," Kenny said.

The project has set abuzz the old hangars at the Marine Corps Air Station in Tustin. The structures were built to hold blimps during World War II. Now workers zip around in cherry-pickers, and the airship's silvery surface shines against the warm tones of the aging wood of the walls.

"You could take this vehicle and go to destinations that have been destroyed, where there's no ports, no runways, stuff like that. This vehicle could go in there, offload the cargo even if there's no infrastructure, no landing site for it to land on, this vehicle can unload its whole payload," said Kenny.

Next, Aeros wants to build a full-size 450-foot-long vehicle that can carry 66 tons of payload.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-01-30-Military%20Airship/id-c706e74aece54dd6a306115a15881937

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Menendez says he reimbursed donor for 2 jaunts

FILE - In this Jan. 28, 2013 file photo, Sen. Robert Menendez, D-N.J. speaks on Capitol Hill in Washington. Menendez's office says he traveled on a plane owned by a Florida physician who is a friend and political donor, but denied that the senator had engaged with prostitutes in the Dominican Republic. (AP Photo/J. Scott Applewhite, File)

FILE - In this Jan. 28, 2013 file photo, Sen. Robert Menendez, D-N.J. speaks on Capitol Hill in Washington. Menendez's office says he traveled on a plane owned by a Florida physician who is a friend and political donor, but denied that the senator had engaged with prostitutes in the Dominican Republic. (AP Photo/J. Scott Applewhite, File)

(AP) ? Sen. Robert Menendez's office says he reimbursed a prominent Florida political donor $58,500 for the full cost of two of three trips Menendez took on the donor's plane to the Dominican Republic in 2010.

There was no public disclosure.

"The senator paid for the two trips out of his personal account and no reporting requirements apply," said Menendez spokeswoman Tricia Enright.

Details of Menendez's trips emerged as his office said unsubstantiated allegations that the senator engaged in sex with prostitutes in the Dominican Republic are false.

The FBI searched the West Palm Beach, Fla., office of the donor ? eye doctor Salomon Melgen ? on Tuesday night and early Wednesday, but it was unclear if the raid was related to Menendez, a New Jersey Democrat.

A third trip by Menendez aboard Melgen's plane ? a campaign fundraising journey to the donor's residence in the Dominican Republic ? took place in May 2010. That trip was reported to the Federal Election Commission, said Enright. That trip, for fundraising from the community of Americans in the area, went to the Dominican Republic and to Puerto Rico, said Menendez's office.

Menendez categorized the other two trips as personal. The first was from Aug. 6-9, 2010, a round trip from South Florida to the Dominican Republic. The second personal trip was from Sept. 3-6, 2010, from New Jersey to the Dominican Republic and back.

Menendez could have invoked what is known as a "friendship exemption" regarding the two personal trips, which would have required the senator to report the travel to the Senate Ethics Committee as a gift. Instead, Menendez chose to reimburse the full cost of the two trips.

The Daily Caller, a conservative website, reported shortly before the November election that Menendez traveled on Melgen's private plane to the Dominican Republic to engage in sex with prostitutes.

Menendez's office said the accusations of engaging with prostitutes "are manufactured by a politically motivated right-wing blog and are false."

At FBI headquarters in Washington, spokesman Jason Pack said the bureau "cannot comment on the existence or status of an investigation." Justice Department spokeswoman Tracy Schmaler also declined to comment.

On Tuesday, Menendez became chairman of the Senate Foreign Relations Committee, succeeding Sen. John Kerry, D-Mass.

Records filed in Palm Beach County show an Internal Revenue Service lien against Melgen of more than $11.1 million for unpaid taxes from 2006-09. Prior liens for taxes from 1998 to 2002 were subsequently withdrawn, records show.

Earlier Wednesday, Menendez's office said Melgen has been a friend and political supporter of the senator for many years and said the three trips Menendez took have been "paid for and reported appropriately." Menendez's office later changed the statement's wording to specify that the trips had been "paid for or reported appropriately" to correct the impression that all three trips had been publicly reported.

The Daily Caller began publishing stories about Menendez and Melgen on Nov. 1, when it reported that two women from the Dominican Republic said Menendez paid them for sex earlier in 2012. Prostitution is legal in the Caribbean nation.

Melgen is involved in numerous businesses, all sharing the same address in West Palm Beach, according to records filed with the Department of State in Florida.

Late Tuesday and early Wednesday, FBI agents were seen inside the West Palm Beach building, walking its halls and standing beside shelves full of files.

Melgen is listed as having an ownership interest in DRM Med Assist, which Federal Aviation Administration records show is the owner of a CL-600 Challenger plane. Flight records for the aircraft were not immediately available.

Melgen, a registered Democrat, has made $193,350 in political contributions since 1998, including $14,200 to Menendez, according to Federal Election Commission records. Menendez was chairman of the Senate Democratic Campaign Committee, which raises money for Democratic Senate candidates, from 2009-11.

Menendez, a lawyer, is a former mayor of Union City, N.J., and also served in the New Jersey state General Assembly and the New Jersey state Senate. He is divorced and has two children.

Melgen, 58, is a native of the Dominican Republic, where he earned his medical degree from the Universidad Nacional Pedro Henr?quez Ure?a in 1978. He has lived in the U.S. since at least 1980, holding an internship, residency and fellowship at hospitals in Connecticut, Missouri and Massachusetts, according to records filed with the Florida Department of Health.

Melgen has been licensed to practice in Florida since 1986 and purchased the West Palm Beach plot of land where he built his main office in 1991. Over the years, Melgen has become regarded as a top ophthalmologist, speaking at conferences and even operating on then-Gov. Lawton Chiles in 1997. The governor later appointed Melgen to a state panel on HMOs.

Calls to Melgen's offices Wednesday were forwarded to an answering service where receptionists told callers to try back Thursday. Calls to Melgen's home in North Palm Beach, which is appraised at $2.1 million, went unanswered.

On the website for his medical practice, Melgen writes: "I am always asked what sets me apart from most other doctors, and I would have to say that I do not consider myself to be a 'cookbook' physician. My patients are my number one priority, and when I am looking to treat a diagnosis I try to look at all the data at hand and extrapolate the best treatment instead of solely adhering to what the current 'standard' of treatment may be."

___

Associated Press writers Matt Sedensky in West Palm Beach, Fla., Curt Anderson in Miami and Jack Gillum and Larry Margasak in Washington contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-01-31-Menendez/id-dce8ec224bbc44c9aec88411e419d6fa

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Wednesday, January 30, 2013

As The Auto Insurance Industry Spends Billions, Fewer Drivers ...

All those ads trying to wheedle, cajole, convince and otherwise get drivers to switch car insurers add up to billions of dollars for insurance companies. But a new study says that even with all that financial heft, fewer drivers are deciding to take the plunge and go elsewhere. That sound you hear is money sliding down the drain.

Last year only around 9% of policyholders, about $12 billion worth of premiums, switched to another car insurer, say consultants at McKinsey & Co. (via the Wall Street Journal).

Apparently that?s quite a slide from the 12% who did so in 2009 and 2010, when people used comparison shopping to buy insurance that could save them a few bucks after the recession.

In order to lure new customers, marketing expenditures for insurers jumped 21% in 2010 to $5.1 billion before ticking up to $5.9 billion in 2011. The numbers for 2012 aren?t out yet but that dollar amount is expected to have risen yet again.

Geico spends the most, at $1 billion in marketing costs reported in 2011, followed by State Farm at $813.5 million and Allstate at $745.3 million.

Throwing all that firepower at drivers isn?t quite working, however, as the people who are usually the target of such advertising are quite price-sensitive and??is not as large or as valuable as the marketing firepower aimed at them would indicate,? the report said.

Only 27% shopped around in 2011 and then a third of those decided to switch insurance coverage from one business to another, while the rest stayed put and didn?t even take a peek elsewhere.

Things aren?t going to change anytime soon, say experts ? the companies will continue to shell out dough to try and woo those stubborn customers. Even though??the industry as a whole is treading water; some carriers are spending heavily for brand recognition and have little to show for it? in market-share growth, McKinsey?s report said. Still, ?this expensive battle for customer consideration isn?t going away.?

Bombarded by Ads, Few Drivers Switch Car Insurer [Wall Street Journal]

Source: http://consumerist.com/2013/01/30/as-the-auto-insurance-industry-spends-billions-fewer-drivers-switching-insurers/

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Tuesday, January 29, 2013

Forensic Astronomer Cracks the Case of Historic Meteor Procession

It was a cloudy winter night along the northeastern United States in February 1913, so most people might not have noticed anything unusual around 9 PM, but for a lucky few with clearer conditions ? and a penchant for staring up at the night sky ? there was a spectacular display of a series of fireballs moving from one end of the horizon to the other, following the same trajectory. It was a meteor procession ? an exceedingly rare event in which a meteor breaks up when it hits the Earth?s atmosphere. Normally, a meteor burns up as it plunges to Earth, but the fiery fragments in a procession travel in a nearly horizontal path running parallel to the surface of the Earth.

The meteor procession of February 9, 1913, captured newspaper headlines all over the northeast, and inspired a painting by Canadian astronomer Gustav Hahn. We?re approaching the 100th anniversary of that display, so it?s fitting that Donald Olson ? a self-described ?forensic astronomer? at Texas State University ? has a new article (co-authored by Steve Hutcheon of Australia?s Astronomical Association of Queensland)? in Sky and Telescope detailing his latest analysis of historical accounts describing the procession.

I?ve been a fan of Olson?s quirky research for years, and wrote about his findings several times for Discovery News. There was his intriguing hypothesis that the moon may have contributed to the sinking of the Titanic. He helped clear up confusion among historians as to the precise? location of Julius Caesar?s landing site when the Roman general invaded Britain in 55 B.C. He showed that Mary Shelley was probably telling the truth about a moonlit ?waking dream? that inspired her to pen Frankenstein. And he?s studied nagging astronomy-related issues in Chaucer?s Canterbury Tales, the photography of Ansel Adams, and Edvard Munch?s ?The Scream? (likely inspired by a blood-red sky at sunset, an after-effect of the 1883 eruption of Mount Krakatoa in Indonesia)

Depiction of the 1913 meteor procession by Canadian artist Gustav Hahn. Credit: University of Toronto Archives (A2008-0023), ? Natalie McMinn

Nor is this the first time Olson has tacked meteor procession. There was another such event in 1860, he discovered, one that likely inspired a classic poem by Walt Whitman, ?Year of Meteors?:

Nor the comet that came unannounced out of the north flaring in heaven,
Nor the strange huge meteor-procession dazzling and clear shooting
over our heads,
(A moment, a moment long it sail?d its balls of unearthly light over
our heads,
Then departed, dropt in the night, and was gone;)

Originally historians assumed that Whitman was referring to the 1833 or 1858 Leonid meteor storms, or a well-documented meteor that fell in 1959, but Olson suspected that there might be a record of a meteor procession in the historical record around the samr time. There was: he found several eyewitness accounts and newspaper reports of ?a spectacular procession of multiple fireballs? on July 20, 1860. It even inspired yet another artist, Frederic Church, ?The Meteor of 1860.? (Artists seem to like incorporating astronomical events into their paintings.)

Frederic Church's "The Meteor of 1860." Public domain.

Olson came across the Church painting and the Whitman mystery a few years after stumbling upon Hahn?s canvas (Hahn was an amateur astronomer) in an article by astronomer Clarence Chant, who evocatively described the ?slow, majestic motion of the bodies., and almost equally remarkable was the perfect formation which they retained.?

Hahn?s painting also? had an inscription: ?Meteor display of February 9, 1913, as seen near High Park.?He quickly recognized the similarities between the Hahn and Church scenes, and from there made the connection to the Whitman poem.

Which brings us to Olson?s latest work. William F. Denning penned an article about the 1913 procession in Nature in 1916, observing that its extended trajectory seemed unparalleled in astronomical history. Based on reports from ship navigators around the world, as well as other eyewitness accounts, it seemed to space more than 6000 miles. Later that year, in the Journal of the Royal Astronomical Society of Canada, he renewed his call for more navigational reports, since these were the best means of definitively confirming the range of the procession?s trajectory.

Olson and Hutcheon answered the call, albeit 100 years later. They combed through vast maritime archives and found seven new ship reports from that era. based on their subsequent analysis, they were able to extend the range of the 1913 procession?s trajectory by another 1000 miles. ?The track now goes more than 7000 miles ? that?s more than a quarter of the way around the world,? Olson said via press release. His new analysis is ?the most complete map ever drawn of the ground track of the procession.?

References:

Chant, C. (1913). ?An Extraordinary Meteoric Display?. Journal of the Royal Astronomical Society of Canada 7: 145?19.

Olson, Donald and Hutcheon, Steve. ?The Great Meteor Procession of 1913,? Sky and Telescope, February 2013.

Pickering, W. H. (1922) ?The Meteoric Procession of February 9, 1913, Part I? in Popular Astronomy, 30: 632.

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Source: http://rss.sciam.com/click.phdo?i=6e8395482be601c40730f5fd860390f7

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Using Self Improvement To Improve Your Mind, Body And Mood ...

Monday, January 28th, 2013. Author : Max Cohen. 13 views.

Sometimes when you first step onto the road of personal development, it can all be a little overwhelming. There are also a lot of different improvement avenues to chose from. Personal development can range from improving your diet to enhancing your social skills. Self improvement can be achieved in many different ways. The main goal of personal development is to improve the way that you feel about yourself, but it is quite probable that others around you will notice the changes too.

Set realistic, attainable goals for yourself to ensure that you are envisioning an achievable, healthy lifestyle. By taking some time our for yourself to focus on both strengths and weaknesses, you will notice overall self-improvement.

Take the time to research the lives of successful people. Studying the processes used by others will help you better develop your own self improvement strategies. Knowing that other people have succeeded at the same goal will make it seem more attainable to you.

Be on the lookout for new ways to challenge yourself. Discovering new challenges is a great way to open yourself up to new possibilities. You can learn more and acquire new skills. You may even start a new model by doing something that has never been done before. Do something new and unique, instead of copying others.

TIP! Seeking advice from a counselor, or paster can be a wonderful source to help guide you. They have a great deal of experience in dealing with personal thoughts and are even licensed to do so.

When you are actively trying to improve yourself, failing to do well at something can hurt your self-esteem more than it otherwise would. Actually, failure is really a learning experience. Failure is a way of learning your weaknesses and your strengths. Looking at it this way, failure is a source of pride, because you?ve unlocked another piece of the puzzle when it comes to your development.

Get organized. You will feel accomplished and your mind will feel clearer. This also helps relieve you from stress caused by disorganization. When everything is in a proper place, life is a bit more calm.

Take the time to change the focus of your conversation from your own accomplishments and awards to the achievements of those around you. You?ll be able to find out about the wonderful things the people you know have accomplished, bringing about a new-found respect and admiration for them.

Find texts that help you. This could be a holy text for some people. For others, it could just a book of inspirational sayings. Sometimes having a physical representation of comfort can help you better manage your day-to-day life.

TIP! Make the most of your work time to accomplish more. One trick to doing this, is to take more breaks.

Improving your life is closely tied to willpower, and a lot can be said for the karma you develop along the way. This means that you are wise to only wish good things upon others. If you endeavor to be positive about all things, then that positivity will come back to you.

Learn to deal with stressful situations without reacting in an emotional way. Learning ways to maintain your composure when stressed will help boost your self-esteem, and help you triumph under any circumstance. Breathing deeply can be a powerful way to reduce stress and stay in the moment.

The worst way to deal with a situation is by overreacting. This will cause you unneeded and unnecessary stress. It?s best to train yourself to cope with your daily stress, and it begins with analyzing every situation where you tend to feel strained. If you screw up, you can probably fix it, or at least find a way to minimize the damage. Rather than dwelling on what you?ve lost, look at the things you still have.

Leadership is about exercising authority, but good leaders are humble, too. When delivering criticisms, remember that you should be firm, yet friendly. You will not go far if you forget your own willingness to serve. A successful leader is one who demonstrates integrity and virtue as an example to others.

TIP! Writing out your goals will help you develop your own plan for personal growth. Record the behaviors and character traits you wish to have; for example, you might list patience or gratitude.

It is impossible for you to properly care for the ones you love, unless you take care of yourself first. It doesn?t matter if you are succeeding or failing in your path. You should always find time to rest your body so that you can renew yourself.

Strive to improve daily so that each one is more perfect than the previous. Set a goal of continuous improvement through steady efforts. Try your hardest to achieve something different today than what you achieved yesterday.

Make a list of your priorities, and plan your life around these elements. When it comes to focusing your feelings and emotions, strive to apply them to the important aspects of your life that build happiness, and do not waste them on the negative aspects that weigh you down and prevent inner peace.

Your core principles are important, and your actions should reflect them. Everyone has basic principles by which they define themselves. Having a good foundation based on your core principles will benefit your sense of self esteem. Better yet, this practice encourages consistency, which is an excellent character trait to maintain.

TIP! Live your life with wisdom and humility. There are certain things in your life that you just can?t change.

Anytime and anywhere, be ready for when your ideas strike. Make sure you have a notepad on you at all times. Scribble detailed notes when something comes to you, and then carry them out whenever your creativity is piqued.

It is essential to have a clearly outlined goal, when working toward improving self improvement. Make sure to come up with a target goal for yourself. If you are clear about your goals, it will be easier to measure how well you have achieved them.

Our goal in this article was to help you to accomplish a start on your self improvement plans. However, there are many other ways in which you may further improve your life. No matter your age, you can always work on becoming a better person for both yourself and others.

Maintaining a positive attitude will get you through a lot of tough times while allowing you to grow and mature. If you do not have a good attitude you will never get as far as you could have. Maintain a positive approach to life in order to reach your goals.

TIP! One new trait that is being researched and is very important to develop is known as sexual capitol. It does not refer to using sexuality in a manipulative way.

This is a Guest Post. Read more about the author here: Click Here

Using Self Improvement To Improve Your Mind, Body And Mood

Source: http://rodt-st.com/using-self-improvement-to-improve-your-mind-body-and-mood/

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HP web store leaks 14-inch Chromebook Pavilion, to be unveiled on February 17

HP crafting 14inch Chromebook Pavilion, to be unveiled on February 17

Hewlett-Packard didn't have the best 2012, but that's not stopping the US company from getting on the Chromebook bandwagon. The HP Chromebook Pavilion was spotted by Slashgear on HP's own web store, despite the additional information section noting a February 17 "ad embargo" on the information. The little 14-inch Chromebook runs Google's eponymous OS with an Intel Celeron 847 CPU clocked at 1.1GHz, an Intel HD GPU, 2MB of DDR3 SDRAM (expandable up to 4GB), and 16GB of SSD storage space, put to use on the 14-inch HD BrightView LED-backlit display (1366 x 768 resolution). A trio of old-school USB 2.0 slots an HDMI out, and an ethernet jack make up the lion's share of ports, while an SD card slot adds expandable storage options. The 2.55Ah lithium-ion battery included will last up to (approximately) four hours and 15 minutes, though we'd like to put that to the test ourselves before trusting the specs sheet. Of course, it looks like it won't be too long before we hear more and get our hands on the device, given that Feb. 17th date.

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Via: Slashgear

Source: Hewlett-Packard (PDF)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/rnez1HWBYZQ/

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China says concerned by Japan's move to boost military

BEIJING (Reuters) - China expressed concern on Monday after Japan unveiled plans to boost the number of its military personnel, as a bitter territorial dispute between the two countries drags on.

Japan's Defence Minister Itsunori Onodera said on Sunday the government would increase the number of personnel, now standing at about 225,000, by 287 in the next fiscal year starting in April, the biggest rise in two decades. The figure represents an expansion of about 0.1 percent.

Chinese Foreign Ministry spokesman Hong Lei said Japan should pay greater attention to regional concerns, alluding to Japan's at times brutal behavior during World War Two which China considers Japan has not done enough to atone for.

"Due to historical reasons, Japan's neighboring countries pay great attention to its military developments," Hong told a daily news briefing.

"We hope that Japan pursues a path of peaceful development, respects the concerns of countries in the region, take history as a mirror and does more to benefit regional peace and stability," he added.

China and Japan are engaged in an increasingly hostile dispute over a group of uninhabited islands in the East China Sea.

Both sides sought to cool tension last week, with Chinese Communist Party chief Xi Jinping telling an envoy from Japanese Prime Minister Shinzo Abe that he was committed to developing bilateral ties.

China's own military advances have rattled the region, including developing stealth fighters and launching the country's first aircraft carrier.

On Sunday, the government said it had again tested emerging military technology aimed at destroying missiles in mid-air.

(Reporting by Ben Blanchard; Editing by Robert Birsel)

Source: http://news.yahoo.com/china-says-concerned-japans-move-boost-military-091054325.html

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Monday, January 28, 2013

President Obama, Hillary Clinton: From Bitter Rivals to Bosom Buddies

In something of a parting gift, President Obama is making abundantly clear his deep support and fondness for outgoing Secretary of State Hillary Clinton, who is leaving wide open a possible presidential run in 2016.

Sitting together for their first joint interview, you could almost forget that they once politically bludgeoned each other in the 2008 Democratic primary.

"I'm going to miss her," Obama told CBS News' Steve Croft. "Wish she was sticking around."

"A few years ago it would have been seen as improbable," Clinton admitted, before explaining that she ultimately agreed to take the position as secretary of state "because we both love our country."

"I'll tell you what I finally thought. You know, if the roles had been reversed, and I had ended up winning, I would have desperately wanted him to be in my cabinet," Clinton said.

Sitting casually next to each other, laughing and smiling, the president and Clinton praised one another effusively.

"I consider her a strong friend," Obama said, while Clinton described their relationship as "warm" and "close."

Obama said he proposed the joint interview because he wanted to publicly say "thank you" to Clinton for all of her hard work. For those eagerly looking for hints of Clinton's future ambitions, however, the interview certainly felt like a political endorsement.

Clinton notably offered no outright denial, when asked about her plans for 2016.

"Obviously the president and I care deeply about what's going to happen for our country in the future and I don't think either he or I can make predictions about what's going to happen tomorrow or the next year," she said.

"I am still secretary of state and forbidden from even hearing these questions," Clinton joked when asked about her future.

The president brushed off the question.

"You guys are incorrigible," he told Croft of the press. "I was inaugurated four days ago and you're talking about elections four years from now."

Clinton declared herself in good health, following her concussion last December that led to a blood clot.

"I still have some lingering effects from falling on my head and having the blood clot," she said, still wearing her glasses. "But the doctors tell me that will all recede. And so, thankfully, I'm looking forward to being at full speed."

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Source: http://news.yahoo.com/president-obama-hillary-clinton-bitter-rivals-bosom-buddies-022602363--abc-news-politics.html

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Sunday, January 27, 2013

Uribana Prison Riot Kills Dozens In Barquisimeto, Venezuela (GRAPHIC PHOTOS)

CARACAS, Venezuela -- Venezuela's top prisons official said the government was evacuating a prison Saturday after a deadly riot that reportedly left dozens of people dead amid a clash between National Guard soldiers and armed inmates.

Penitentiary Service Minister Iris Varela said officials decided to evacuate all inmates from the Uribana prison in the central city of Barquisimeto after the bloodshed on Friday in order to "close this chapter of violence." Varela said inmates were being taken to other facilities. She spoke in a televised news conference and did not immediately give a death toll.

(WARNING: GRAPHIC PHOTOS BELOW)

Vice President Nicolas Maduro called the violence tragic and said Prosecutor General Luisa Ortega Diaz and National Assembly President Diosdado Cabello would lead the investigation.

"The prisons have to be governed by law," Maduro said on television early Saturday.

Humberto Prado, an activist who leads the watchdog group Venezuelan Prisons Observatory, said inmates' relatives and media accounts put the toll at 55 killed and 88 injured.

The Venezuelan newspaper Ultimas Noticias and the television channel Globovision reported more than 50 killed, both citing Ruy Medina, the director of Central Hospital in the city.

Relatives wept outside the prison during the violence, and cried at the morgue Saturday as they waited to identify bodies.

Varela said Friday that the riot broke out when groups of inmates attacked National Guard troops who were attempting to carry out an inspection.

Varela said the violence had affected a number of prisoners and officials, but said the authorities would hold off until control had been re-established at the prison to confirm the toll. She said the government decided to send troops to search the prison after receiving reports of clashes between groups of inmates during the past two days.

The death toll provided by Medina rose late Friday after he had initially reported four killed and dozens injured. Ultimas Noticias reported that the victims included a Protestant pastor and a member of the National Guard, as well as inmates.

Opposition leader Henrique Capriles condemned the government's handling of the country's overcrowded and violent prisons.

"Our country's prisons are an example of the incapacity of this government and its leaders. They never solved the problem," Capriles said on his Twitter account. "How many more deaths do there have to be in the prisons for the government to acknowledge its failure and make changes?"

The Venezuelan Prisons Observatory said in a statement that in 2007 the Costa Rica-based Inter-American Court of Human Rights had ordered the government to seize weapons that inmates had in their possession at Uribana prison and to take measures to avoid deaths in the facility. The group called for the government to release a list with the names of the dead and wounded in Friday's violence, as well as details about weapons seized in the search.

"No one doubts that inspections are necessary procedures to guarantee prison conditions in line with international standards, but they can't be carried out with the warlike attitude as (authorities) have done it," Prado told The Associated Press in a telephone interview. "It's clear that the inspection wasn't coordinated or put into practice as it should have been. It was evidently a disproportionate use of force."

Prado's group says Uribana prison was built to hold up to 850 inmates but currently has about 1,400.

It was the latest in a series of bloody riots in the country's severely overcrowded prisons where inmates often freely obtain weapons and drugs with the help of corrupt guards. Venezuela currently has 33 prisons built to hold about 12,000 inmates, but officials have said the prisons' population is about 47,000.

In April and May, a prison uprising in La Planta prison in Caracas blocked authorities from going inside for nearly three weeks. One prisoner was killed and five people were wounded, including two National Guard soldiers and three inmates.

Two months later, another riot broke out at a prison in Merida, and the Venezuelan Prisons Observatory reported 30 killed.

In August, 25 people were killed and 43 wounded when two groups of inmates fought a gunbattle inside Yare I prison south of Caracas.

Chavez's government has previous pledged improvements to the prison system, but opponents and activists say the government hasn't made progress.

Varela, the prisons minister, said news media including Globovision and a local newspaper had run reports on the inspections, which she said had in fact been a "trigger for the violence."

Prado denied that, saying: "The problem isn't the work of the media. The problem is that the government hasn't disarmed the prison population."

___

Associated Press writer Ian James contributed to this report.

"The prisons have to be governed by law," Maduro said.

Humberto Prado, an activist who leads the watchdog group Venezuelan Prisons Observatory, said inmates' relatives and media accounts put the toll at 55 killed and 88 injured.

The Venezuelan newspaper Ultimas Noticias and the television channel Globovision reported more than 50 killed, both citing Ruy Medina, the director of Central Hospital in the city.

Relatives wept outside the prison during the violence, and cried at the morgue Saturday as they waited to identify bodies.

Penitentiary Service Minister Iris Varela said Friday that the riot broke out when groups of inmates attacked National Guard troops who were attempting to carry out an inspection.

Varela said the violence had affected a number of prisoners and officials, but said the authorities would hold off until control had been re-established at the prison to confirm the toll. She said the government decided to send troops to search the prison after receiving reports of clashes between groups of inmates during the past two days.

The death toll provided by Medina rose late Friday after he had initially reported four killed and dozens injured. Ultimas Noticias reported that the victims included a Protestant pastor and a member of the National Guard, as well as inmates.

Opposition leader Henrique Capriles condemned the government's handling of the country's overcrowded and violent prisons.

"Our country's prisons are an example of the incapacity of this government and its leaders. They never solved the problem," Capriles said on his Twitter account. "How many more deaths do there have to be in the prisons for the government to acknowledge its failure and make changes?"

The Venezuelan Prisons Observatory said in a statement that in 2007 the Costa Rica-based Inter-American Court of Human Rights had ordered the government to seize weapons that inmates had in their possession at Uribana prison and to take measures to avoid deaths in the facility. The group called for the government to release a list with the names of the dead and wounded in Friday's violence, as well as details about weapons seized in the search.

"No one doubts that inspections are necessary procedures to guarantee prison conditions in line with international standards, but they can't be carried out with the warlike attitude as (authorities) have done it," Prado told The Associated Press in a telephone interview. "It's clear that the inspection wasn't coordinated or put into practice as it should have been. It was evidently a disproportionate use of force."

Prado's group says Uribana prison was built to hold up to 850 inmates but currently has about 1,400.

It was the latest in a series of bloody riots in the country's severely overcrowded prisons where inmates often freely obtain weapons and drugs with the help of corrupt guards. Venezuela currently has 33 prisons built to hold about 12,000 inmates, but officials have said the prisons' population is about 47,000.

In April and May, a prison uprising in La Planta prison in Caracas blocked authorities from going inside for nearly three weeks. One prisoner was killed and five people were wounded, including two National Guard soldiers and three inmates.

Two months later, another riot broke out at a prison in Merida, and the Venezuelan Prisons Observatory reported 30 killed.

In August, 25 people were killed and 43 wounded when two groups of inmates fought a gunbattle inside Yare I prison south of Caracas.

Chavez's government has previous pledged improvements to the prison system, but opponents and activists say the government hasn't made progress.

Varela, the prisons minister, said news media including Globovision and a local newspaper had done reports on the inspections, which she said had in fact been a "trigger for the violence."

Prado denied that, saying: "The problem isn't the work of the media. The problem is that the government hasn't disarmed the prison population."

Also on HuffPost:

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Source: http://www.huffingtonpost.com/2013/01/26/uribana-prison-riot-kills-dozens-venezuela_n_2558484.html

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China economy to underpin global demand in 2013: CIC

BEIJING (Reuters) - China's economy could grow at more than 8 percent in 2013, giving some underpinning to global economic activity that is set for a mild, tortuous recovery this year, the head of China's sovereign wealth fund said on Saturday.

"China's economic growth could be over 8 percent this year. China's economy supports a very large part of global demand," Lou Jiwei, chairman of the China Investment Corp. (CIC) , told a forum.

China's economy expanded an annual rate of 7.9 percent in the fourth quarter of 2012, snapping seven consecutive quarters of weaker growth, as a raft of pro-growth policies kicked in.

The Q4 bounce helped lift full year growth in the world's second biggest economy to 7.8 percent which, though China's slowest pace for 13 years, generated roughly a third of global economic growth of 3.2 percent - itself the worst since the 2009 financial crisis and just barely above the 3 percent mark economists say signals a worldwide recession.

Lou said that even if China's growth did accelerate further in 2013, increased financial market volatility caused by Europe's debt crisis and concerns about the U.S. fiscal position, left the world economy set for a "mild, tortuous and slow recovery" at best.

Problems in debt-constrained countries, though, meant opportunities for cash-rich China, Lou said, adding that the government should encourage local firms to step up their efforts to expand and invest abroad.

"There are big opportunities for countries with cash on their hands, especially for China. We should grasp the opportunities and give firms more freedom in investing overseas," he said.

China has accumulated the world's biggest store for foreign reserves, some $3.31 trillion as at the end of 2012, generated largely as a function of capital controls that have forced Chinese exporters to sell foreign currency to the central bank.

Easing capital controls to let firms more readily use export earnings to buy overseas assets would please many executives who say strict rules and a lengthy approval process for outbound investments are big impediments to doing cross-border deals.

Despite the difficulties, Chinese non-financial outbound foreign direct investment hit a record $14.7 billion in December, taking the 2012 total to $77.2 billion from 2011's $60.1 billion, Commerce Ministry data shows.

Beijing targets a total of $560 billion in outbound foreign direct investment in the five years to end 2015.

REFORMS NEED POLITICAL COURAGE

Zeng Peiyan, a former vice-premier, told the same forum that China's leaders must have "political courage" to quicken economic reforms to help sustain long-term growth.

Zeng, now chairman of top Beijing think-tank the China Centre for International Economic Exchanges (CCIEE), said the Chinese economy was "shifting gear" and clearly decelerating from the double-digit average growth rates of the past three decades to 7-8 percent in the foreseeable future.

Chen Xiwen, deputy director of the office of the Central Financial Work Leading Group, a powerful body that charts key government economic policies, said China's growth strategy should focus on improving urbanization in its next stage of development.

Chen, who also heads the ruling Communist Party's office on rural policy, said China's actual urbanization rate is around 35 percent - lower than the official rate of 51 percent.

"In other words there are some 200 million (rural) people who have entered cities, but have not yet become urban residents. This is a big problem that we need to deal with in the future urbanization process," he said.

China's rigid household registration, or hukou, rules are seen by many analysts as China's most pressing reform item as a change there would address inequality and boost domestic demand, rebalancing the core growth drivers of the economy.

The millions of migrant workers who have entered cities from the 250 million-strong rural workforce are denied access to services like health and education, forcing them to save hard and constraining spending that would boost domestic consumption.

Spreading the benefit of China's ascent to its position as a global economic powerhouse is widely seen as the best way of quelling the risk of popular revolt and officials have pledged to gradually loosen hukou controls.

A newly recalibrated official index this month indicated China's gap between rich and poor was so wide that serious social dissatisfaction may be brewing.

(Reporting by Kevin Yao; Editing by Nick Edwards and Ron Popeski)

Source: http://news.yahoo.com/china-economy-underpin-global-demand-2013-cic-062007182--sector.html

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Uganda again arrests leading opposition politician Besigye

KAMPALA (Reuters) - Leading opposition politician Kizza Besigye was arrested for planning anti-government riots in the Ugandan capital Kampala, police said on Saturday.

Besigye has led protests for years aimed at toppling President Yoweri Museveni, to whom he lost a presidential election in February 2011. He denounced that poll as fraudulent.

His supporters were at the forefront of widespread anti-government protests against the high cost of living in 2011 and, after a lull last year, they led demonstrations again in October and Besigye was arrested.

Besigye has lost three elections against Museveni, who has been in power for more than 26 years, and stepped down as leader of Uganda's biggest opposition party, Forum for Democratic Change (FDC) last year, but is still a popular politician.

Earlier this week police banned opposition leaders from clearing up rubbish in Kampala's suburbs, saying it was a cover for staging public protests.

"Following attempts to unlawfully assemble and carry out riotous demonstrations ... Dr. Kizza Besigye has been arrested this morning," police said in a statement.

The opposition holds a range of grievances against Museveni, accusing him of seeking to be president for life as well as failing to tackle corruption and rights abuses.

Major western donors withheld aid to the east African country of 33 million people last month citing graft claims in the prime minister's office.

FDC secretary general, Alice Alaso, told Reuters Besigye had been arrested outside his home as he drove out.

Alaso said she visited Besigye at Kira police station, about 13 km (8 miles) from the city center, where he was being held.

Police stopped her giving him a bottle of water, she said.

"Their aim is to starve him ... how can you arrest someone when he has committed no crime?" she said.

Police did not say what charges they would bring against Besigye, who went for medical treatment in Kenya in 2011 after he was nearly blinded with chemical spray by police breaking up demonstrations.

(Reporting by Elias Biryabarema; Editing by Louise Ireland and Duncan Miriri)

Source: http://news.yahoo.com/uganda-again-arrests-leading-opposition-politician-besigye-140600795.html

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Saturday, January 26, 2013

P53 mutation hinders cancer treatment response

Jan. 25, 2013 ? Scientists from the National Cancer Centre Singapore (NCCS) have discovered the workings of the gene that has been hindering treatment response in cancer patients. This discovery was made after 5 years of studying the mutant form of the p53 gene, the major tumor suppressor in humans, which is generally found mutated in over 50% of all type of human cancers.

The dominant-negative (DN) effect of the mutant p53 gene in cancers was found to affect the outcome of cancer treatment modalities. DN effect is a phenomenon whereby one copy of mutant p53 that exists in cancer cells inhibits the tumor suppressor activity of the other wild-type p53 copy when they co-exist. The result is that a patient may either have poor response or earlier relapse of tumours after their treatment.

The research findings is significant in that it offers hope to improve cancer treatment outcomes by selectively inhibiting mutant p53's DN effect through several methods by generating selective and specific inhibitory molecules specific for some of the common hot-spot p53 point mutations. There are currently no drugs or compounds that can alleviate DN effects of mutant p53.

In order to understand the specific roles of mutant p53 DN properties in regulating acute treatment response and long-term tumourgenesis, a team of five researchers led by NCCS Prof Kanaga Sabapathy, the Principal Investigator in the Laboratory of Carcinogenesis and Head of the Division of Cellular & Molecular Research from NCCS, carried out experiments by generating genetically engineered knock-in mouse strains expressing varying levels of mutant p53. The results showed that DN effect is observed after acute p53 activation by a variety of chemotherapeutic drugs and irradiation, thereby affecting anti-cancer treatment. This breakthrough came after five years of intensive research.

It was found that mutant p53 have DN effects in a cell-type and dose-dependent manner, especially during acute p53 activation where p53 levels are elevated. Based on the above observations, efforts to generate specific inhibitors for the common hot spot p53 point mutations are underway. The inhibition of mutant p53 expression in cells carrying a wild-type and mutant p53 alleles can improve response to chemotherapeutic drugs.

In a further study, the researchers also questioned the possibility of the mutant p53 acquiring new functions (or Gain of Function) to drive carcinogenesis, transforming normal cells to cancerous cells. Their investigation comparing cells from genetically engineered mouse strains expressing 2 different types of p53 mutations: the R172H mutation versus the R246S mutation, which showed that Gain of Function (GOF) was found only in the former. This showed that GOF of mutated p53 is specifically dependent on mutation-type but not across all kinds of genetic mutations, highlighting diversity in properties of the different types of p53 mutations, thereby indicating that mutations found in human cancers can behave differently, and thus, need to be carefully assessed prior to treatment.

Thus, the existence of mutant p53 certainly has a negative impact on cancer treatment, whether it is through DN effect or GOF. Prof Sabapathy said that the team is now embarking on more research to determine the possibility of targeting mutant p53 without affecting wild-type p53 in human cells, paving way to clinical trials in the future to test the efficacy on cancer therapeutic response.

The research was supported by grants from the National Medical Research Council of Singapore and the Singapore Millennium Foundation to KS. The publication has been accepted and published by Cell Press, publisher of biomedical journals, in the journal Cancer Cell, on Dec. 10, 2012. Prof Sabapathy also teaches at the Duke-NUS Graduate Medical School.

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Story Source:

The above story is reprinted from materials provided by SingHealth, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Ming?Kei Lee, Wei?Wei Teoh, Beng?Hooi Phang, Wei?Min Tong, Zhao?Qi Wang, Kanaga Sabapathy. Cell-type, Dose, and Mutation-type Specificity Dictate Mutant p53 Functions In?Vivo. Cancer Cell, 2012; 22 (6): 751 DOI: 10.1016/j.ccr.2012.10.022

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/EAuE68IgufU/130125111331.htm

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Newtown residents to join gun control march in DC

Gun rights and gun control advocates demonstrate in the Pennsylvania Capital building Wednesday, Jan. 23, 2013, in Harrisburg, Pa. As a boycott continued to grow over a ban on assault weapons at next month's Eastern Sports and Outdoor Show in Harrisburg, gun rights supporters and gun control supporters held rallies at the state Capitol.(AP Photo/Matt Rourke);

Gun rights and gun control advocates demonstrate in the Pennsylvania Capital building Wednesday, Jan. 23, 2013, in Harrisburg, Pa. As a boycott continued to grow over a ban on assault weapons at next month's Eastern Sports and Outdoor Show in Harrisburg, gun rights supporters and gun control supporters held rallies at the state Capitol.(AP Photo/Matt Rourke);

(AP) ? Residents from Newtown, Conn., are joining a march on Washington for gun control on Saturday with parents, pastors, survivors of gun violence and Education Secretary Arne Duncan.

Organizers said they are expecting thousands of participants for the rally on the National Mall, including about 100 from Newtown and buses from New Jersey, New York and Philadelphia. Others are flying in from Seattle, San Francisco and even Alaska. They will gather Saturday at the Capitol Reflecting Pool at 10 a.m. and will begin marching down Constitution Avenue toward the Washington Monument at 11 a.m. A rally is planned on the monument grounds at noon.

Molly Smith, the artistic director of Washington's Arena Stage, and her partner organized the march, inspired by the December massacre that killed 20 first graders and six teachers at Sandy Hook Elementary School in Newtown, she said. The gunman also fatally shot his mother and committed suicide.

"With the drum roll, the consistency of the mass murders and the shock of it, it is always something that is moving and devastating to me. And then, it's as if I move on," Smith said. "And In this moment, I can't move on. I can't move on.

"I think it's because it was children, babies," she said. "I was horrified by it."

While she's never organized a political march before, Smith said she was compelled to press for a change in the law. The march organizers support President Barack Obama's call for a ban on military-style assault weapons and high-capacity ammunition magazines as well as for universal background checks for gun sales. They also want lawmakers to require gun safety training for all buyers of firearms.

As a theater person, Smith said murdering a child is something you can never show in theater. Even in the Greek tragedy, "Medea," the main character kills her children, but that happens off stage, Smith said.

After the Connecticut shootings, Smith posted something on Facebook and drew more support to do something. The group One Million Moms for Gun Control, the Washington National Cathedral and two other churches eventually signed on to co-sponsor the march. Organizers have raised more than $46,000 online to pay for equipment and fees to stage the rally.

Lawmakers from the District of Columbia and Maryland are scheduled to speak. Actress Kathleen Turner is expected to appear, along with Marian Wright Edelman of the Children's Defense Fund and Colin Goddard, a survivor from the Virginia Tech massacre.

Smith said she supports a comprehensive look at mental health and violence in video games and films. But she said the mass killings at Virginia Tech and Aurora, Colo., and Newtown, Conn., all start with guns.

"The issue is guns. The Second Amendment gives us the right to own guns, but it's not the right to own any gun," she said. "These are assault weapons, made for killing people."

___

March on Washington for Gun Control: http://www.guncontrolmarch.com/

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-01-26-Gun%20Control%20March/id-17eda5b64b864590b1446b7e352127f8

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New target for rheumatoid arthritis drugs

Jan. 25, 2013 ? Researchers at Hospital for Special Surgery have identified a potential new target for drugs to treat patients with rheumatoid arthritis (RA), a protein known as IRHOM2. The finding could provide an effective and potentially less toxic alternative therapy to tumor necrosis factor-alpha blockers (TNF-blockers), the mainstay of treatment for rheumatoid arthritis, and could help patients who do not respond to this treatment. Efforts to develop drugs that hone in on this new target are underway.

"This study is an elegant example of the capacity of basic science cell biologists to work with translational rheumatologists to address a clinically relevant question at a basic level," said Jane Salmon, M.D., Collette Kean Research Chair and co-director, Mary Kirkland Center for Lupus Research at Hospital for Special Surgery (HSS) in New York City, and an author of the study. "We have identified a clinically relevant target that can be applied to patients in the near term." The study will appear online, ahead of print, on January 25, in the Journal of Clinical Investigation and in the February 2013 print issue.

Rheumatoid arthritis, an autoimmune disease, is triggered, in large part, by TNF-alpha, a small signaling protein usually involved in launching protective systemic inflammatory responses. With excessive TNF production, however, immune cells can become activated inappropriately and cause tissue inflammation. This produces a number of diseases, including RA. While TNF-blockers help many RA patients, these treatments are very expensive, and some patients do not respond. For this reason, researchers have been searching for alternative targets in patients with inflammatory diseases against which drugs can be directed.

"TNF can be thought of as a balloon tethered to the surface of cells. To work, it must be cut loose by signaling scissors called TACE (TNF-alpha converting enzyme)," said Carl Blobel, M.D., Ph.D., program director of the Arthritis and Tissue Degeneration Program at HSS. While blocking TACE could be another way to treat rheumatoid arthritis, researchers know this strategy would likely have side effects since patients lacking TACE are prone to skin infections and intestinal lesions.

Earlier this year, HSS investigators demonstrated that the TACE scissors are regulated by molecules called IRHOM1 and IRHOM2, which are thought to wrap around TACE and help it mature into functional scissors. They also demonstrated that mice that are genetically engineered to lack IRHOM2 lack functional TACE on the surface of their immune cells and don't release TNF. Surprisingly, these mice are healthy, and do not develop skin or intestinal defects.

In the current study, HSS researchers set out to investigate why this paradox exists. After examining tissues of IRHOM2-deficient mice, they found that IRHOM2 regulates TACE on immune cells, whereas IRHOM1 is responsible for helping TACE mature elsewhere in the body, such as in brain, heart, kidney, liver, lung and spleen cells. "IRHOM2 appears to have a more restrictive and exclusive function in immune cells," said Dr. Blobel.

The researchers then set out to determine whether blocking IRHOM2 could be a strategy to treat RA. They used a mouse model that mimics human rheumatoid arthritis in mice genetically engineered to be deficient in IRHOM2. They found that these rodents did not develop inflammatory arthritis and were otherwise healthy.

"When we tested mice that don't have IRHOM2 in a model for inflammatory arthritis, we found they were protected and they were protected as well as mice that didn't have any TNF," said Dr. Blobel. "Because TNF is the driver of rheumatoid arthritis in human disease, as evidenced by how well anti-TNF drugs work, we feel that this provides a completely new angle on blocking TNF release. It would be wonderful to be able to inactivate TACE in a tissue-specific manner and IRHOM2 provides a unique mechanism for us to do so."

Using drugs that inactivate IRHOM2 in humans, clinicians will be able to block the function of TACE only in immune cells. "We can prevent the deleterious contribution of TACE to rheumatoid arthritis patients and preserve its protective function in skin and intestines," said Dr. Blobel. "With IRHOM2, we have a unique and unprecedented opportunity to inactive TACE only in certain cell types, and not in others, and there is currently no other effective way of doing that."

The researchers say the next step is to identify antibodies or pharmacological compounds that can be used to block the function of IRHOM2 and are safe in patients. These HSS investigators are currently working to identify and test such agents. "In theory, IRHOM2-targeted drugs will have less toxicity than TNF alpha blockers," said Dr. Salmon. "They block TNF release only from specific cells, those known to contribute to joint inflammation and damage."

Dr. Salmon and Dr. Blobel are co-senior authors of the study. Other investigators involved in the study are from Weill Cornell Medical College, New York City; Ontario Cancer Institute, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada; Heinrich-Heine University, Dusseldorf, Germany; TriInstitutional Laboratory of Comparative Pathology, New York City; and Keio University, Tokyo, Japan.

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Story Source:

The above story is reprinted from materials provided by Hospital for Special Surgery.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Priya Darshinee A. Issuree, Thorsten Maretzky, David R. McIlwain, S?bastien Monette, Xiaoping Qing, Philipp A. Lang, Steven L. Swendeman, Kyung-Hyun Park-Min, Nikolaus Binder, George D. Kalliolias, Anna Yarilina, Keisuke Horiuchi, Lionel B. Ivashkiv, Tak W. Mak, Jane E. Salmon, Carl P. Blobel. iRHOM2 is a critical pathogenic mediator of inflammatory arthritis. Journal of Clinical Investigation, 2013; DOI: 10.1172/JCI66168

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/oyUne2dxrpw/130125142044.htm

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Friday, January 25, 2013

US jobless claims drop to 5-year low of 330,000

(AP) ? The number of Americans seeking unemployment aid fell last week to the lowest level in five years, evidence that employers are cutting fewer jobs and may step up hiring.

The Labor Department said Thursday that weekly unemployment benefit applications dropped 5,000 to a seasonally adjusted 330,000. That's the fewest since January 2008.

The four-week average, a less volatile measure, fell to 351,750. That's also the lowest in nearly five years.

The decline may reflect the government's difficulty adjusting its numbers to account for layoffs after the holiday shopping season. Layoffs spike in the second week of January and then plummet. The department seeks to adjust for those seasonal trends, but the figures can still be volatile.

If the trend holds up, fewer applications would suggest the job market is improving.

"Encouraging news on the U.S. jobs front, even when you remove all of the noise," said Jennifer Lee, an economist at BMO Capital Markets. "Weekly data are noisy, particularly at this time of year, so keep that in mind."

Applications are a proxy for layoffs. They have fluctuated between 360,000 and 390,000 for most of last year. At the same time, employers added an average of 153,000 jobs a month. That's just been enough to slowly push down the unemployment rate, which fell 0.7 percentage points last year to 7.8 percent.

There have been other positive signs for the economy and job market.

The once-battered housing sector is recovering, which is boosting construction and home prices. Home builders started work in 2012 on the most new homes in four years. And sales of previously occupied homes reached their highest level in five years last year. Still, home building and sales remain below the levels consistent with a healthy economy.

More home building will likely increase job growth. In December, the economy gained 30,000 construction jobs ? the most in 15 months. And economists expect construction firms to add more jobs this year as the housing recovery strengthens.

Patrick Newport, an economist at IHS Global Insight, forecasts that construction companies will add 140,000 jobs this year, up from a meager 18,000 in 2012.

The number of people continuing to claim benefits is also falling. There were nearly 5.7 million people receiving unemployment aid in the week ended Jan. 5, the latest data available. That's down from almost 5.9 million in the previous week.

The overall economy grew at an annual rate of 3.1 percent in the July-September quarter. But economists believe activity slowed considerably in the October-December quarter to a rate below 2 percent or less, in part because companies cut back on restocking.

Less restocking leads to slower factory production, which weighs on economic growth.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-01-24-Unemployment%20Benefits/id-1b199998e38748f0a92fa46163b89053

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Kurosawa, Hashimoto, Kikushima and Oguni Named 2013 Jean ...

WGAW Names Japanese Filmmakers Akira Kurosawa, Shinobu Hashimoto, Ry?z? Kikushima, and Hideo Oguni 2013 Jean Renoir Award Honorees?

LOS ANGELES --?The Writers Guild of America, West (WGAW) has named a quartet of iconic Japanese filmmakers ? Akira Kurosawa, Shinobu Hashimoto, Ry?z? Kikushima, and Hideo Oguni ? as honorees of its 2013 Jean Renoir Award for Screenwriting Achievement, given to an international writer(s) who has advanced the literature of motion pictures and made outstanding contributions to the profession of screenwriter.?

The four screenwriters, among other honorees, will be feted at the 2013 Writers Guild Awards West Coast ceremony on Sunday, February 17, at the JW Marriott Los Angeles L.A. LIVE.

?Our Jean Renoir Award, honoring those non-U.S. writers whose work has raised the bar for all of us, this year goes to Akira Kurosawa, Hideo Oguni, Ry?z? Kikushima, and Shinobu Hashimoto, honoring the writing at the heart of the Japanese cinema,? said WGAW Vice President Howard A. Rodman. ?These four men, working in loose collaboration, are responsible for writing many, many masterpieces ? films that reflect the Japanese culture, and have given all of us a taste of the sublime.?

AKIRA KUROSOWA
Writer-director-producer Akira Kurosawa was born in 1910 in Tokyo, Japan and died in 1998 at the age of 88. During his six-decade career, the celebrated filmmaker directed over 30 films ? and wrote or contributed to over 70 titles. Following a brief stint as a painter, Kurosawa entered the film industry in 1936. After learning his craft as an assistant director (often working under director Kajiro Yamamoto) and screenwriter on numerous films, he made his directorial debut in 1943 with the well-received action film Sanshiro Sugata (co-written with Tsuneo Tomita), following this effort up with his breakthrough film Drunken Angel, casting a then-unknown actor Toshiro Mifune, forming a long-term creative partnership, as they would go on to collaborate on some 16 films together.

Following a key piece of advice that mentor Yamamoto gave him early on in his career ? ?a good director needs to master screenwriting? ? Kurosawa would go on to ultimately write or co-write all of the films that he directed, as well as pen screenplays for peer Japanese directors.

Emerging as a maverick talent with a signature eye and voice, Kurosawa?s impressive run of award-winning, acclaimed films played a pivotal role in exposing Japanese cinema to a global audience, their critical and commercial success drawing increased attention to his fellow Japanese filmmakers in the Western world. His seminal films include his first major international hit Rashomon (1950), which won an honorary Academy Award for most outstanding foreign language film, the Venice Film Festival?s Golden Lion Award, and National Board of Review Awards for Best Director and Best Foreign Film; the touching human drama Ikiru (1952), which won a Special Prize of the Senate at the Berlin International Film Festival, the epic adventure Seven Samurai (1954), which won the Venice Film Festival?s Silver Lion, received two Oscar nominations, and was later remade as the classic Western The Magnificent Seven (1960); Throne of Blood (1957), Kurosawa?s riveting take of William Shakespeare?s ?Macbeth,? The Hidden Fortress (1958), which earned a Silver Berlin Bear at the Berlin International Film Festival for Best Direction and provided what many consider the narrative blueprint for George Lucas? ?70s sci-fi blockbuster Star Wars; The Bad Sleep Well (1960), High and Low (1963), Red Beard (1965), Dodes?ka-den (1970), Dersu Uzala (1975), and a pair of rollicking samurai comedies, Sanjuro (1962) and Yojimbo (1961), which was first remade as Sergio Leone?s 1964 spaghetti Western A Fistful of Dollars, then later as 1996 actioner Last Man Standing. His other notable early films include The Men Who Tread on Tiger?s Tail (1945), One Wonderful Sunday (1947), Stray Dog (1949), Scandal (1950), and The Idiot (1951).

Although less prolific in his later years, his final two epics ? Kagemusha (1980), co-written with Masato Ide, which earned the Cannes Film Festival?s Palme d?Or and a Best Direction BAFTA Award, as well as two Oscar nominations, including Best Foreign Language Film, and Ran (1985), co-written with Oguni and Ide, a sprawling adaptation of William Shakespeare?s ?King Lear,? which earned four Academy Award nominations, including Best Director for Kurosawa (and an Oscar for Best Costume Design for Emi Wada), as well as a BAFTA Award for Best Foreign Film and National Board of Review Awards for Best Director and Best Foreign Film ? cemented Kurosawa?s reputation as one of the most important, influential filmmakers in the history of cinema. Recognizing him as a filmmaking master, Kurosawa received an honorary Academy Award for lifetime achievement in 1990 for his ?cinematic accomplishments that have inspired delighted, enriched and entertained worldwide audiences and influenced filmmakers throughout the world.?

Kurosawa?s later, smaller-scale films include 1990?s Dreams, an idiosyncratic, personal work based on his own dreams, 1991?s Rhapsody in August, written by Kurosawa and based on the novel ?Nabe no Naka? by Kiyoko Murata, which received Japanese Academy Award nominations for Best Director and Best Screenplay, and his final film, 1993?s Madadayo, written by Kurosawa and based on essays by Hyakken Uchida). In 1999, he received a posthumous Lifetime Achievement Award from the Japanese Academy, as well as 2001 Japanese Academy Award for Best Screenplay for After the Rain (1999). In 1982, Kurosawa received a Career Golden Lion Award at the Venice Film Festival, and a decade later in 1992, he received a Lifetime Achievement Award from the Directors Guild of America for his body of film work.

In his memoir, Something Like an Autobiography, Kurosawa wrote, ?With a good script a good director can produce a masterpiece; with the same script a mediocre director can make a passable film. But with a bad script even a good director can?t possibly make a good film. For truly cinematic expression, the camera and the microphone must be able to cross both fire and water. That is what makes a real movie. The script must be something that has the power to do this... If your goal is to become a film director, you must master screenwriting,? adding: ?At some point in the writing of every script I feel like giving the whole thing up. From my many experiences of writing screenplays, however, I have learned something: If I hold fast in the face of this blankness and despair, adopting the tactic of Bodhidharma, who glared at the wall that stood in his way until his legs became useless, a path will open up.?

?The WGAW?s Jean Renoir Award is meant to shine light upon that path ? one that Mr. Kurosawa, Mr. Oguni, Mr. Kikushima, and Mr. Hashimoto so elegantly and movingly blazed for the rest of us,? said Rodman.

RY?Z? KIKUSHIMA
Screenwriter Kikushima was born in 1914 and died in 1989. Having written or contributed to over 60 films during his lifetime, Kikushima was a frequent creative collaborator with director Kurosawa, co-writing many classic films together, beginning with Stray Dog (1949), and continuing with Scandal (1950), Throne of Blood (1957, co-written with Kurosawa, Oguni, and Hashimoto, based on the William Shakespeare?s play ?Macbeth?), The Last Fortress (1958, co-written with Kurosawa, Oguni, and Hashimoto), The Bad Sleep Well (1960, co-written with Kurosawa, Oguni, Hashimoto, and Eijiro Hisaita), Yojimbo (1961, co-written by Kurosawa), Sanjuro (1962, co-written with Kurosawa and Oguni), High and Low (1963, co-written with Kurosawa, Oguni, and Eijiro Hisaita), which received an Edgar Allan Poe Award nomination for Best Foreign Film, and Red Beard (1965, co-written with Kurosawa, Oguni, and Masato Ide), among other Kurosawa titles.

Kikushima?s additional screenwriting or co-writing credits include films such as Tange Sazen (co-written with Masashige Narusawa, based on a serial story by Itsuma Maki, 1952), Till We Meet Again (1955, based on the novel by Yasushi Inoue), A Will o? the Wisp (Onibi, 1956), Arashi (1956, based on a story by Toson Shimazaki), Last Day of the Samurai (1957, co-written by Tokuhei Wakao), Kistune to tanuki (1959), Naruse?s breathtaking When A Woman Ascends the Stairs (1960), Afraid to Die (co-written with Hideo Ando), 500,000 (1963), the WWII U.S.-Japanese military epic Tora! Tora! Tora! (1970, Screenplay by Larry Forrester and Hideo Oguni and Ryuzo Kikushima, Based on the book by Gordon W. Prange), Willful Murder (1981, based on the book by Kimio Yada), which earned Kikushima a Japanese Academy Award nomination for Best Screenplay, Prince from the Moon (co-written with Shinya Hidaka, Kon Ichikawa, and Mitsutoshi Ishigami, based on the novel Taketori Monogatari by Shikibu Murasaki), and The Demon Comes in Spring (1989, based on the novel by Tokuhei Suchi).

SHINOBU HASHIMOTO
Born in 1918 and a frequent collaborator as part of Kurosawa?s creative team, Hashimoto wrote or contributed to some 61 films, including several films that have achieved classic status: Rashomon, Ikiru, The Bad Sleep Well, Sanjuro, High and Low, Dodes'ka-den, and Ran, among others. Over the course of his career, Hoshimoto has earned five Best Screenplay Blue Ribbon Awards, for Rashomon (1951, shared with Kurosawa), Darkness at Noon (1957), The Chase and Summer Clouds (both 1958), Harakiri (1963), and The Great White Tower (1967).

Hashimoto?s additional screenwriting or co-screenwriting credits include Kubi (1968), Tidal Wave (1973), and Hakkodasan (1977) and Village of Eight Gravestones (1977), both of which earned Japanese Academy Best Screenplay nominations. He also earned a quintet of Best Screenplay Kinema Junpo Awards for the films Samurai Rebellion (1967), Japan?s Longest Day (1967), The Castle of Sand (1974, shared with Yoji Yamada), The Great White Tower (1966), The Bad Sleep Well (1960, shared with Kurosawa), and The Hidden Fortress (shared with co-writer Kurosawa), Yoru no tsuzami, and The Chase (all 1958).

HIDEO OGUNI
As this Japanese creative team's senior member, screenwriter-director-producer Oguni wrote or contributed to over 100 films during his career, including cinematic classic such as Ikiru, Throne of Blood, The Hidden Fortress, The Bad Sleep Well, Sanjuro, High and Low, Dodes'ka-den, and Ran, collaborating with Kurosawa as his most frequent screenwriting partner from the 1950s through the mid-1980s. Born in 1904 in Aomori, Japan, Oguni died in 1996 at age 91.

Named after influential filmmaker Jean Renoir, the WGAW?s lifetime achievement international screenwriting award is given on an occasional basis to honor screenwriters working outside the U.S. and in other languages. Previous WGAW Jean Renoir Award honorees include late Italian screenwriters Suso D'Amico (in 2009) and Tonino Guerra (in 2011).

For press photos, click here.

The 2013 Writers Guild Awards will be held on Sunday, February 17, 2013, at simultaneous ceremonies at the JW Marriott L.A. LIVE in Los Angeles and the B.B. King Blues Club in New York City. For more information about the 2013 Writers Guild Awards, please visit www.wga.org or www.wgaeast.org.

For media inquiries about the 2013 Writers Guild Awards Los Angeles show, please contact Gregg Mitchell in the WGAW Communications Dept. at: (323) 782-4651 or email:?Gregg Mitchell, or visit online at: www.wga.org.

For media inquiries about the 2013 Writers Guild Awards New York show, please contact Jay Strell at Sunshine Sachs at (212) 691-2800 or email:?Jay Strell; or visit online at: www.wgaeast.org.

The Writers Guild of America, West (WGAW) is a labor union representing writers of motion pictures, television, radio, and Internet programming, including news and documentaries. Founded in 1933, the Guild negotiates and administers contracts that protect the creative and economic rights of its members. It is involved in a wide range of programs that advance the interests of writers, and is active in public policy and legislative matters on the local, national, and international levels. For more information on the WGAW, please visit: www.wga.org.??

Source: http://www.wga.org/content/default.aspx?id=5168

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