First Friday RVA, March 2013: Coming In Like A Lion | Gay ...

Wake up, wake up, wake up, and head on down to the Art Walk! Here are some things to look out for once you get there.

Read More: art whino, art6, arts, First Friday, gallery at unos, ghost print, necci, RVA Mag, studio 6, visual art studio

By Andrew Necci for RVA Mag

It?s the beginning of the third month of the year, and the weather has no idea what it?s doing. Rain yesterday, sunshine today, cold and cloudy tomorrow? It?ll all settle into place eventually, I?m sure. In the meantime, with the winter doldrums finally being driven away, it?s the perfect time for you to go check out some art. And luckily for you, First Friday is right around the corner!?It always seems to sneak up on us when the first Friday of the month is also the?first of the month, and that?s even more true in February, which is missing a few days for some reason. The galleries are ready, though?there are a lot of great shows out there this month, just waiting for you to discover them, so wake up, wake up, wake up, and head on down to the Art Walk! Here are some things to look out for once you get there:

Ghostprint Gallery: The Spoils Of St. Hubris

The Spoils of Saint Hubris?is the first part of an ongoing body of work entitled?The Spoils. The inspiration for the paintings is the story of St. Hubert and Arthurian Legend. Hundley uses his intense skill as a conceptual image-maker to symbolically portray human ambition and how culture attempts to bring order from chaos. These works are an exploration of timeless themes and bridge the chasm between technology and tradition in both content and method. Says Hundley, ?I navigate the gauntlet of abstraction to arrive just this side of representational.? One of the most highly acclaimed illustrators of the past decade, Hundley?s commercial work has appeared in magazines from Rolling Stone to the Atlantic Monthly, and from Broadway, to the Grammy?s, even Major League Baseball. He holds accolades from the Society of Illustrators New York and the Illustrators Club in Washington, DC, and is frequently featured in articles in Communication Arts magazine. Hundley currently serves as an Associate Professor in the Department of Communication Arts at Virginia Commonwealth University?s School of the Arts. He is the Director of the Richmond, Virginia branch of The Art Department, an innovative, international art and design program that offers a hybrid of online and hands-on studio training.

The Spoils Of St. Hubris?will open with an artist?s reception on Thursday, February 28, from 6-8 PM, and with a First Friday opening reception on Friday, March 1, from 6-9 PM, at?Ghostprint Gallery, located at 220 W. Broad St. It will remain on display through April 27.

Art Whino: Sewn Well

Art Whino presents?Sewn Well: The Solo Show Of Toobz Muir

The subjects of Toobz? work seems to be at once perfect in their imperfection. In this reality, his soft treatment of these features contributes a beauty of what may in a different light seem deformed. The artist?s unique perspective derives from his father?s calcium deficiency which led to many facial reconstructions and a catalyst for the artist?s work. ?Sewn Well? refers to the aritst?s life experience, it enables him to see the beauty within and look past the exterior to find what is real, it allows him the ability to create beauty that is one of a kind.

Sewn Well?opens with a reception on First Friday, March 1st, from 7-10 PM, at?Art Whino Gallery?s Richmond branch, located at 202 W. Broad St.

The Gallery At UNOS: The Colors Of Life

The Gallery At UNOS presents works by three artists?painter Jinx Constine, photographer Daphne Reid, and kidney recipient Saifur Rahman.

Jinx Constine is a traditional oil painter of Virginia landscapes who has recently expanded her style to include lyrical abstracts in acrylics on paper. As the mother of a daughter with cystic fibrosis, Jinx is active with the Cystic Fibrosis Foundation and organizations that support organ donation and transplantation.

Daphne Reid?fondly remembered by many as Aunt Vivian from?The Fresh Prince Of Bel-Air?has traveled all over the world capturing the colorful images of portals, doors, and gates. The entire collection is now available in her book Doors, which can be purchased at?daphnemaxwellreid.com.

Saifur Rahman received a life-saving kidney transplant in June 2010 at the VCU Medical Center/Hume-Lee Transplant Center. Saifur, who is not professionally trained, paints and sketches as a way to relax and have fun.

The Colors Of Life?opens with a reception on First Friday, March 1, from 5-7:30 PM, at?The Gallery At UNOS, located at 700 N. 4th St. The exhibit will remain on display through April 27.

Visual Art Studio: Creating For Environmental Awareness

Dogwood Blooms?by Susan Hribernik, 24? x 30? framed photograph

Visual Art Studio Gallery presents?Creating for Environmental Awareness, an interactive and selected works group exhibition.

Join us and other concerned citizens in the gallery as we create and display art work that has us thinking about how we treat our environment, each other and what our future might look like. This exhibiton is designed to get us talking in advance of Earth Day and is based on similar exhibitions at various U.S. chapters of?Citizens Climate Lobby. Clearly, we need to think of our impact on our world through-out the year and as part of our daily lifes to preserve it and keep it beautiful for 1,000s (millions!) of years to come. There is a Richmond chapter of this national non-profit for those who would like to become more involved.

Creating For Environmental Awareness?will open with a reception on First Friday, March 1, from 7-10 PM at?Visual Art Studio, located at 208 W. Broad St. The exhibition will remain on display through March 28.

Studio 6: Open Studio

On First Friday, March 1, Todd Hale presents a display of recent work at?Studio 6, located at 6 E. Broad St., beginning at 6 PM.

Art6: A Woman?s Touch

Art6 presents?A Woman?s Touch, an all-women?s art exhibit featuring works by Elie Ellis (front room gallery), Corey Heilman (2nd room gallery), and a group exhibit of works by various female artists in the main gallery, curated by Helene Ruiz of The Urban Individualists. The exhibition will open First Friday, March 1, with a reception from 6-10 PM featuring a live performance by Ajna Tribal, at?Art6, located at 6 E. Broad St. The exhibit will remain on display throughout the month of March.

Books Bikes & Beyond: Kid Havoc Issue Zero

Books Bikes & Beyond presents?Kid Havoc Issue Zero, an exhibit of artwork from the new comic series Kid Havoc, by Eric Scott Pfeiffer.?Kid Havoc Issue Zero?will open with a reception on First Friday, March 1, at 7 PM, at?Books Bikes & Beyond, located at 7 W. Broad St. The exhibition will remain on display until March 31.

Storefront For Community Design: The City I Live In

An exhibition of very large posters at mOb + Storefront is opening March 1 from 5 to 9 pm. Designers were asked to create a visual interpretation of the city they live in?ranging from New York, Gothenburg, past, present, future, dark, green, Richmond, etc. Styles are diverse, the walls are bright, and demonstrate the need to respect the poster as a critical component of our city streets.

The City I Live In?opens with a reception on First Friday, March 1, from 5-9 PM, at?The Storefront For Community Design, located at 205 W. Broad St.

Art 180: What Do You Stand For?

Art 180 presents a retrospective public exhibition,?What Do You Stand For??The exhibition, in Art 180?s new teen art center, Atlas, documents the entire project which featured eight-foot tall self-portraits that travelled all over the city of Richmond, celebrating identity and purpose. The portraits were created by 25 sixth-grade students in the summer of 2011.

Come celebrate the end to an exciting journey for these portraits, and check out our new home!

What Do You Stand For??opens with a reception on First Friday, March 1, from 6-9 PM, at?Art 180, located at 114 W. Marshall St. (new location!) The exhibition will remain on display through mid-April.

Candela Books & Gallery: Subject To Change

Candela Books & Gallery presents?Subject To Change, an exhibition of works by Maggie Taylor.

Maggie Taylor creates enigmatic and surrealistic photographic montages through digital means. Found objects, photographs by the artist, vintage tintypes and various ephemera are collected and placed directly onto a flatbed scanner. The scanned elements are layered and manipulated in Adobe Photoshop to create magical worlds akin to a folk art of dreams, or clandestine inner landscapes. One such image can take several months to create and include up to 60 layers of imagery.

Taylor studied philosophy at Yale before obtaining an MFA in photography at University of Florida. She lives and works in Gainesville, Florida with her husband, Jerry Uelsmann. Taylor?s digital composites are included in public and private collections, among them The Center for Creative Photography, Tucson; The George Eastman House, Rochester; Ogden Museum of Southern Art, New Orleans; The Cleveland Museum of Art, Cleveland; and The Fogg Art Museum, Harvard University.

Her work is also published in Landscape of Dreams, Peachpit Press, Berkeley, 2005; Solutions Beginning with A, Modernbook Editions, Palo Alto, 2007; Alice?s Adventures in Wonderland by Lewis Carroll, Modernbook Editions, Palo Alto, 2008; and No Ordinary Days, University Press of Florida, 2013, among others.

Subject To Change?opens with a preview and artist talk on Thursday, February 28, from 5-8 PM, followed by a First Friday opening reception on Friday, March 1, from 5-9 PM, at?Candela Books & Gallery, located at 214 W. Broad St. The exhibition will remain on display through April 27.

Gallery A: New Work by Myron Helfgott

Gallery A presents an exhibition of new work by Myron Helfgott.

The structure of the work I have been making in recent years has been influenced by literature, film, and architecture. With the use of electric motors, audio chips, slide projectors, video cameras and projectors, and traditional sculptural materials I have attempted to address such diverse subjects as the self-portrait, landscape painting, and gender and age transformation. The major influences for these works are literary. In addition to the literary structure, I have included criticism of the work within the body of the work as has Vladimir Nabokov, Federico Fellini, and Philip Roth. I see the work as a symbiotic relationship of diverse elements. Trying to harness the diverse content and materials in these sculptures is like trying to organize debris at a picnic on a windy day.

I began life intellectually at the age of 21, involved with Zen and existentialism and it wasn?t until I was confronted by a painting at some museum?struck dumb?mind gone empty ? confronted by the power of its presence did I realize the idea I had about art making needed to be re-examined. The notion that great art stimulates thought quite misses the mark. This realization is consistent with Samuel Beckett?s statement, ?The role of the art object is to render silence? and is reinforced by Stanley Kubrick when he states ?The truth of the thing is the feel of it, not the think of it?. ?Myron Helfgott

New Work by Myron Helfgott?opens Thursday, February 28 with an artist?s reception from 5-9 PM featuring music by the Kevin Johnson Group, at?Gallery A, located at 114-A Virginia St. The exhibition will remain on display through April 20.

Studio Two Three: Bump It Mafia

Please join us on First Friday in March as we welcome the?Bump It Mafia?and their portfolio to the walls of Gallery Two Three!

The Bump It Mafia is a group of women who came together with an interest in printmaking and representing strong, intelligent women. Bump It Mafia is a celebration of womanhood in printmaking and highlighting the importance of camaraderie and community not just amongst women, but amongst all artists of all backgrounds.

Participating artists include: Emily Arthur, Heather Bryant, Nicola Buffa, Lisette Chavez, Ana Hurtado-Gonzales, Carrie Lingscheit, Emmy Lingscheit, Rachael Madeline, Kristine Joy Mallari, Saegan Moran, Meghan O?Connor, Kathryn Polk, Coco Rico, Jessica Robles, Andrea Rogers, Linda Santana, Jenny Schmid, Katy Seals, and Cat Snapp.

The Bump It Mafia portfolio exhibit will open with a reception on First Friday, March 1, from 7-9 PM at?Studio Two Three, located at 1617 W. Main St. The exhibit will remain on display through March 29.

The Camel: Rtistjono

This month, The Camel will be displaying the work of local illustrator Jonathan Ashe, aka Rtistjono. There will be an opening reception on First Friday, March 1, starting at 5 PM, and a daytime reception and ?funky brunch,? featuring the music of Oregon Hill Funk All-Stars, on Sunday March 3 starting at 11 AM, at?The Camel, located at 1621 W. Broad St. The exhibit will remain on display throughout the month of March.

Glave Kocen Gallery: Common Ground

Glave Kocen Gallery presents?Common Ground, an exhibition of new works by Jeff Dodge. This exhibit will open with a First Friday reception on Friday, March 1, from 6-9 PM, at?Glave Kocen Gallery, located at 1620 W. Main St. The exhibit will remain on display through March 29.

Red Door Gallery: Richard Fraumeni

?Untitled?, 48? x 48?, oil on canvas

Red Door Gallery presents an exhibit of large abstract paintings by Richard Fraumeni. Fraumeni uses large scale canvases, bold colors and repetitive graphic patterns that engage the viewers perception of depth and movement.

This exhibit will open with a reception on First Friday, March 1, from 6-9 PM, at?Red Door Gallery, located at 1607 W. Main St. It will remain on display through March 30.

Brazier Gallery: Works by Suzanne Clifford-Clark

Brazier Gallery presents an exhibition of new work by Suzanne Clifford-Clark.

My paintings are born in my imagination. They are more about ideas, moods, and feelings than they are about places to which they might bear resemblance. Skies?skies and their enormous, powerful clouds; the glow created by the different lights of day, early morning, and early evening; the audaciousness of storms and their magnificent cloud scapes; as well as the subtlety of quiet dusks?are the never-ending source of my inspiration. And while my painting might begin with a glimmer of reality?a cloud formation that struck me with awe; a pink sky that panned the horizon?I create the oceans, landscapes, and trees to give my skies a point of reference.

My best paintings occur when I put my own, preconceived ideas aside and am open to the conversation that takes place between the painting and myself. I yield to the painting and am open to the dialogue that always has and must take place. This, I find, is the most magical part of the process.

Painting, for me , is a way of manipulating media and colors?of layering, of adding, of subtracting, of scumbling and sanding and glazing?and exploiting all of the infinite qualities of oil paint to take it to any level I need to employ. I work strictly in oils and use high quality linen or canvas. Influenced by the Old Masters such as Narcisse-Virgile Diaz de la Pena and their application of paint, the experience of being in a new place?a place of which I know nothing?is interesting to me, and I endeavor to bring that feeling to the work I do today.??Suzanne Clifford-Clark

This exhibit will open with a First Friday reception on Friday, March 1 from 6-8 PM at?Brazier Gallery, located at 1616 W. Main St. The exhibit will remain on display through March 30.

Page Bond Gallery: Building On The Past & Spheres Of Influence

Page Bond Gallery presents two exhibits:?Building On The Past, a group exhibition of 10 women artists, and?Spheres Of Influence, recent work by Mira Hecht.

Meredith Lachin,?Marriage Portrait, 2012, Oil on canvas, 18 x 24 inches each

In honor of Women?s History Month, the Page Bond Gallery is pleased to present Building Upon The Past: a selection of new works by April Dauscha, Andrea Donnelly, Meredith Lachlin, Mary Ivy Martin, Ginger Metzger, Maria Stabio, Kaleena Stasiak, Sayaka Suzuki, Erin Lynn Welsh, and Augusta Wilson. Curated by Amara Craighill and Sarah Irvin.

This group exhibition brings together 10 emerging women artists. Their works engage directly or indirectly with various roles, symbols, and activities that female artists of previous generations were compelled to challenge or usurp. These include symbols of traditional feminine domesticity, motherhood, marriage, and the female body; the male gaze; and the reclaiming of conventionally feminine art forms such as quilting, embroidery, and needlework.

Some of the questions the exhibition seeks to address are: How is this new generation of artists able to incorporate one or more of these traditionally feminine symbols or roles into their work rather than feel compelled to refuse them? If these artists can be viewed collectively, what distinguishes their outlook from that of previous generations of women artists? What gender-related challenges, if any, do they face in making their work and having it collected, displayed, and reviewed? How do female artists of this generation fit into the multifaceted feminist movement?

Mira Hecht,?Untitled #10, 2009, Oil on canvas, 42 x 57 inches

Mira Hecht?s ?Close to Home? series is another step in her exploration of the formal, emotional, and spiritual properties of the circle. Her intuitive, mandala-like compositions, reminiscent of light refracted through water droplets, have gained much critical acclaim. They are simultaneously dynamic and quiet, strengthened by tensions between surface and depth, and positive and negative space. ?The circle is a vast and mysterious form filled with potential. Inspired by my own contemplative practice and glimpses of perfection within the mind?s eye, each painting is meant to be a small gesture of exaltation, pointing to joy, connection and wholeness,? Hecht says. Her canvases have a meditative quality that rewards extended viewing.

Building On The Past?&?Spheres Of Influence?will open with a reception on First Friday, March 1, from 7-9 PM, at?Page Bond Gallery, located at 1625 W. Main St. Both exhibitions will remain on display through April 1.

Decor Design Center Of Richmond: Contemporary Expressions

Morning Rain, acrylic, 36? x 24?

Decor presents?Contemporary Expressions, a selection of recent work by Karen Kozojet Ching.

Karen Kozojet Ching?s evolving style is a fusion of impressionism and abstract expressionism. All aspects of her life inform her work. ?While I strive to make my paintings aesthetically appealing, the interpretation reaches deep beneath the multi-layered surface.?

Ching?s vibrant paintings capture the essence of landscapes, seascapes and gardens that are inspired by her travels and local surroundings. The expressionistic brushstrokes dance across the canvas in a rhythmic burst of color. The luminosity is achieved through a series of transparent glazes. She adds textural elements with sgraffito, impasto, drips, spatter, collage and iridescent and metallic paints.

Contemporary Expressions?will open with a reception on First Friday, March 1, from 6-9 PM, at?Decor Design Center Of Richmond, located at 19 S. Belmont Ave. The exhibition will remain on display through March 30.

?-

Artists! Galleries!?Would you like your future First Friday events covered in these monthly articles? We might hear about your event anyway, but why leave it to chance? Email your press releases to?andrew@rvamag.com.

By Andrew Necci; top image by Heather Addley

- See more at: http://rvamag.com/articles/full/18229/first-friday-rva-march-2013-coming-in-like-a-lion#sthash.I9qgRATP.dpuf

Source: http://www.gayrva.com/arts-culture/first-friday-rva-march-2013-coming-in-like-a-lion/

erin brockovich dodgeball 2012 pro bowl postsecret ufc on fox 2 supercross christina aguilera etta james funeral

Hey Marissa! Working from home is alive and well

Marissa Mayer issued a company-wide mandate ending telecommuting, requiring employees to come into the office or leave the company. NBC's Brian Williams reports.

By Isolde Raftery, TODAY

When Yahoo relayed to its employees on Friday that they could no longer work remotely, one of the reasons given was that??speed and quality are often sacrificed when we work from home.?

It may seem logical ??the internal Yahoo memo?leaked to The Wall Street Journal's?AllThingsD.com said that some of the ?best decisions and insights come from hallway and cafeteria discussions? ? but workplace experts say that may not be true.

"Telecommuting is associated with significantly higher levels of job satisfaction, lower turnover intentions, reduced role stress, and higher supervisor-ratings of job performance," said?Washington State University psychology professor Tahira Probst via email.?

Probst, who researches workplace issues, added that working from home doesn?t hurt worker-boss relations. ?The data actually suggest telecommuting is associated with a more positive relationship with one?s supervisor.?

Telecommuting has been a growing trend over the past few years. The U.S. Census Bureau reports?that 13.4 million people worked from home at least part-time during a typical week in 2010, and the number of telecommuters in computer, science and engineering fields increased by 69 percent between 2000 and 2010. ?

The federal government has pushed for its employees to be ready to work remotely, should disaster strike. Last fall, thousands of workers were?forced to work remotely?after?Superstorm Sandy knocked out power to much of lower Manhattan.?

Natural disaster aside, when it comes to day-to-day work, Mayer may not be alone in wanting her employees to put in more face time. Google Chief Financial Officer Patrick Pichette didn?t seem keen on telecommuters on a recent trip to Australia. When asked how many Google employees work remotely, Pichette replied,?according to Sydney Morning Herald: ?As few as possible.?

After the Yahoo memo about telecommuting was leaked Friday, critics were swift to call the move anti-woman and anti-family. But the Census reported that more men (51.3 percent) worked from home. Of telecommuters, 64.5 percent reported that they did not have children younger than 18 present in the home.

Carol Roth, a brand consultant for the?virtual office space company Regus, argued that workplace flexibility allows employers to retain the best talent. ?

?I was disappointed to hear about this mandate from Yahoo because they?re a tech company and it?s made us more flexible and allowed us to work from anywhere,? Roth said. ?To say that the only way to be connected is if you?re side by side with somebody is completely backward and at odds with their own mission.??

Susan Cain,?author of "Quiet," a book about introverts in the workplace, said she thought Yahoo?s decision could hinder creativity.

?The kind of person who is in Silicon Valley is a person who is at the top of their game as an engineer and has a creative mind,? Cain said. ?Also it?s a type of person who wants to control their own destiny much more than working for a corporation. They want to dictate their own working terms. They tend to be pretty committed to what they?re doing.?

In an online (nonscientific) survey NBCNews.com readers also questioned the policy.

My quality of work is much better by telecommuting than by actually working in the office. I'm an introvert and I get stressed out by being around people. When I'm at home working, I can get so much work done because I'm not distracted and stressed out by all those around me.

Wrote another:?

Some managers think that the only way work gets done is to perform bed checks to make sure everyone is at their desk at a certain time and think work only occurs when they are breathing down their necks. Other bad managers can't express what they want done unless they are waving their arms in front of the worker and pointing vaguely at what they want done.

But I've also seen workers that can't hold their attention to the screen when they could be puttering in the garden or in the garage.

Others were more sympathetic.

An employer has a right to ask people to actually COME to work, I think. On the other hand, EVERY employer, even if they don't allow daily telecommuting, should be increasing their family-friendly policies to allow for plentiful personal/sick/vacation time and some flexibility with scheduling when needed. The whole country could benefit from that!

Probst said Yahoo?s decision could result in more stress, more work-family conflict and ?greater intentions to quit working for Yahoo.?

?I don?t think that is what Yahoo is hoping for as a result of their decision,? she said, ?but it may be what they see.?

?

Source: http://lifeinc.today.com/_news/2013/02/26/17091537-is-telecommuting-dead-dont-count-on-it-experts-say?lite

paula deen birth control recall nick carter leslie carter aaron carter sister pfizer signing day 2012 football

Novel combination therapy shuts down escape route, killing glioblastoma tumor cells

Novel combination therapy shuts down escape route, killing glioblastoma tumor cells

Wednesday, February 27, 2013

Glioblastoma, the most common and lethal form of brain tumor in adults, is challenging to treat because the tumors rapidly become resistant to therapy. As cancer researchers are learning more about the causes of tumor cell growth and drug resistance, they are discovering molecular pathways that might lead to new targeted therapies to potentially treat this deadly cancer.

Scientists at the Ludwig Institute for Cancer Research in San Diego worked collaboratively across the laboratories of Drs. Paul Mischel, Web Cavenee and Frank Furnari to investigate one such molecular pathway called the mammalian target of rapamycin or mTOR. This signaling pathway is hyperactivated in close to 90 percent of glioblastomas and plays a critical role in regulating tumor growth and survival. Therapies that inhibit mTOR signaling are under investigation as drug development targets, but results to date have been disappointing: mTOR inhibitors halt the growth but fail to kill the tumor cells.

A study published this week in the Proceedings of the National Academy of Sciences uncovers an unexpected but important molecular mechanism of mTOR inhibitor resistance and identifies a novel drug combination that reverses this resistance.

The story begins with a closer look at a gene-encoded protein called promyleocytic leukemia gene or PML. The study investigators explored the role of PML in causing resistance to mTOR inhibitor treatment. They found that when glioblastoma patients are treated with drugs that target the mTOR pathway, the levels of PML rise dramatically. Further, they showed that PML upregulation made the tumor cells resistant to mTOR inhibitors, and that if they suppressed the ability of the tumor cells to upregulate the PML protein, the tumor cells died in response to the mTOR inhibitor therapy.

"When we looked at cells in in vivo models and patients treated in the clinic, it became clear that the glioblastoma cells massively regulated PML enabling them to escape the effects of mTOR inhibitor therapy," reported senior author Paul Mischel, MD, Ludwig Institute member based at the University of California at San Diego.

"Our team hypothesized that if we could use a pharmacological approach to get rid of PML and combine it with an mTOR inhibitor, it could change the response from halting growth to cell death. The question was how?" added Mischel.

Previous research had shown that the use of low-dose arsenic could cause degradation of the PML protein in patients with leukemia. The team hypothesized that if arsenic could degrade PML, it may reverse resistance to mTOR inhibitors. The combination of mTOR and low-dose arsenic in mice indeed showed a synergistic effect, with massive tumor cell death along with very significant shrinkage of the tumor in mice with no ill side effects.

"Current therapy upregulates PML, turning off the mTOR signaling pathway. The tumor cells hide, waiting for the target signal to return," said Mischel. "When low-dose arsenic is added, not only does it stop the cell from returning, it shuts down the escape route killing the tumor cell."

These results present the first clinical evidence that mTOR inhibition promotes PML upregulation in mice and patients, and that it mediates drug resistance. The clinical relevance was confirmed when researchers looked at before- and after-treatment tissue samples from patients treated with mTOR inhibitors, confirming that PML goes up significantly in post treatment of mTOR inhibitors.

"These data suggest a new approach for potential treatment of glioblastoma," said Mischel. "We are moving forward to test that possibility in people."

Post-doctoral students Akio Iwanami and Beatrice Gini from the Mischel lab as well as Ciro Zanca from the Furnari/Cavenee lab, also contributed significantly to this paper.

###

Ludwig Institute for Cancer Research: http://www.licr.org

Thanks to Ludwig Institute for Cancer Research for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 27 time(s).

Source: http://www.labspaces.net/127038/Novel_combination_therapy_shuts_down_escape_route__killing_glioblastoma_tumor_cells

katie couric barista university of kentucky ncaa oakland news alec baldwin alec baldwin

Researchers discover protein that may control the spread of cancer

Tuesday, February 26, 2013

Researchers at the University of Hawai'i Cancer Center have uncovered a novel mechanism that may lead to more selective ways to stop cancer cells from spreading. Associate Professor Joe W. Ramos PhD, a cancer biologist at the UH Cancer Center and his team have identified the role of the protein RSK2 in cancer cell migration, part of the process of cancer metastasis.

Cancer becomes metastatic when cells break away from the primary tumor and spread to other parts of the body. Metastatic cancer is much more difficult to treat and patients with metastatic cancer have a generally worse prognosis. "The cancers that kill are those that spread to other parts of the body or disseminate within the organ," said Ramos. "If we could keep cancer cells confined to the primary tumor mass, we could remove it with less risk of metastasis and later recurrence."

The Ramos team reports that RSK2 significantly increases cell migration in part by reducing integrin activation. Integrins play an important role in cell adhesion to their surrounding tissue and the migration of tumor cells to new locations in the body. RSK is active in both breast and prostate tumors, and promotes proliferation in these cells. It can also promote cell invasion and metastasis in head and neck cancers in addition to lung cancer and neuroblastoma.

"We focused on understanding the process of cell adhesion," said Ramos. "Integrins help the cell move by grabbing onto proteins and cells in their surroundings, pulling, then releasing and grabbing on again. Blocking a cancer cell's ability to adhere and move can control further dissemination of some metastasis. There are drugs that kill cancer cells and there are drugs that stop the division of cancer cells, but there are far fewer drugs that specifically stop the movement of cancer cells. Our work suggests that drugs that interfere with RSKs may help control or prevent metastasis."

###

The study: "RSK2 Protein Suppresses Integrin Activation and Fibronectin Matrix Assembly and Promotes Cell Migration" is published in the December 21, 2012 edition of The Journal of Biological Chemistry. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527930/

University of Hawaii Cancer Center: http://www.uhcancercenter.org/

Thanks to University of Hawaii Cancer Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 47 time(s).

Source: http://www.labspaces.net/127024/Researchers_discover_protein_that_may_control_the_spread_of_cancer

miami heat bulls california earthquake california earthquake tyson chandler tyson chandler stephen hill

Krrbside Questions ? Creating Baby Rooms and Adjusting Your ...

Little additions to the family mean big changes to your home decor. Photo: Thesuperfluities.com

Welcome to?Krrbside Questions, a column created solely to answer your queries about living local and being the good neighbor we know you all are. First up with some super helpful advice is?Jett Superior, recently featured in our?Member Spotlight. This Southern lover of all things secondhand, vintage and handmade has what she calls ?crackerjack ingenuity? and a knack for redoing roadside furniture. Have a burning question? Email us at blog@krrb.com?and we?ll make sure to get it in the right hands.

What are must haves for a baby nursery? Photo: Stickeee.be

Q: We just had a baby boy but never got around to setting up the nursery in the nine months before around-the-clock nursing. What?s absolutely necessary since we don?t have a ton of room or time???

A: Many people do a sort of elaborate staging of a baby?s environment far before they?re born. I know of one woman, I kid you not, who was already planning her nursery two years in advance of having children. However, I think that certain things can be over-planned and certainly overdone. The truth is, no matter how well-prepared you think you are, you?re always kind of behind the eightball when you have a kid.

I think the key for you in particular is really just to keep it simple and streamlined, then trade up as necessary. Buy one large thing, and when your baby is ready to move on to the next stage of development, get rid of it and bring a new piece in. For instance, for their first couple of months my kids got shucked into a sturdy seagrass basket with a custom fitted cushion for naps; it was super-portable and I had total basket envy. I think that if someone made one of those things grown-sized I would lie happily in it for many, many hours every day and never do anything tedious or unnecessary like put on pants or frown. At night the basket attached to a stand and became a bassinet. When our babies outgrew the bassinet, they graduated to a small pack and play before moving on to a convertible crib later.

My definitive starter list as to what I believe you need right now? That?s easy:
A chest of drawers with changing table top to serve as your Baby Central.
A wheeled bassinet or small pack and play crib.
Baby monitor. Even if your place is smallish, you need to be able to listen closely to baby when your little one is sleeping.
A lidded container for disposing of soiled diapers.
Stuff to fill up those drawers in that changing table including books, children?s fever reducer/pain reliever, diaper rash ointment, lotion, thermometer and multiple crib sheets/bedding for the baby.

If you have the space and funds to invest in a decent rocking chair? Do it. Rocking your baby is a special kind of magic that every parent should get to experience.?

Find out how to make this task chair not so mobile.

Q: I have an office?chair?at home that?s dangerous to my learning-to-teeter toddler. Any ideas on how to demobilize my?chair? I am including a pic.?

A: Thanks for thinking to include a picture! It doesn?t tell me everything I need to know about that chair, but it tells me enough. First, it has potential, because the legs are low-profile and many, meaning that it will be a pretty stable chair when you de-wheel it. Doing so should be a fairly straightforward task, by the looks of it. Just flip the chair on its side and pull the casters out. You?ll want to attach a circle of cork or felt where the casters were inserted so as to protect your floors until you get to put the casters back in. ??If the chair seat swivels, there are two ways of approaching it. First, check the underside of the seat. Some swivel chairs have the option to lock the seat so as to keep it fixed. If that?s not the case with this particular chair, then the only option you have is to keep it tucked firmly under your desk when not in use, or placed into a corner so as to anchor the back.?? I hope this helps, and Godspeed to you and your wobbly tot!

Source: http://blog.krrb.com/2013/02/25/krrbside-questions-creating-baby-rooms-and-adjusting-your-home-for-toddlers/

Chopper Live jerry brown michael buble michael buble Jenni Rivera Alive Facebook Down bo jackson

2nd winter storm in days blasts central US

A pedestrian crosses the street in front of a city bus stuck in the snow Tuesday, Feb. 26, 2013 in Kansas City, Mo. The second major snowstorm in a week battered the nation's midsection Tuesday, dropping a half-foot or more of heavy, wet snow across Missouri and Kansas and cutting power to thousands. (AP Photo/The Kansas City Star, Keith Myers)

A pedestrian crosses the street in front of a city bus stuck in the snow Tuesday, Feb. 26, 2013 in Kansas City, Mo. The second major snowstorm in a week battered the nation's midsection Tuesday, dropping a half-foot or more of heavy, wet snow across Missouri and Kansas and cutting power to thousands. (AP Photo/The Kansas City Star, Keith Myers)

A truck makes it's way up the snow covered road in Sedgwick County, Kan. , Tuesday, Feb. 26, 2013. The second major snowstorm in a week battered the nation's midsection Tuesday, dropping a half-foot or more of snow across Missouri and Kansas and cutting power to thousands. Gusting winds blew drifts more than 2 feet high and created treacherous driving conditions for those who dared the morning commute. (AP Photo/The Wichita Eagle, Bo Rader)

A pair of snow plows head west on US-54 Highway, clearing the snow off the roadway, near Cheney, Kan., Tuesday, Feb. 26, 2013. The second major snowstorm in a week battered the nation's midsection Tuesday, dropping a half-foot or more of snow across Missouri and Kansas and cutting power to thousands. Gusting winds blew drifts more than 2 feet high and created treacherous driving conditions for those who dared the morning commute. (AP Photo/The Wichita Eagle, Bo Rader)

A pedestrian passes snow covers cars and trees Tuesday, Feb. 26, 2013 in Kansas City, Mo. The second major snowstorm in a week battered the nation's midsection Tuesday, dropping a half-foot or more of heavy, wet snow across Missouri and Kansas and cutting power to thousands. (AP Photo/The Kansas City Star, Keith Myers)

KANSAS CITY, Mo. (AP) ? The second major snowstorm in a week battered the nation's midsection Tuesday, dropping up to a foot or more of heavy, wet snow that strained power lines and cut electricity to more than 100,000 Midwesterners. At least three deaths were blamed on the blizzard. Gusting winds blew drifts more than 2 feet high and made driving treacherous for those who dared the morning commute.

About 105,000 homes and businesses in northwest Missouri, northeast Kansas and western Oklahoma were without power before noon as the snow weighed heavily on power lines and tree limbs. Up to 10 inches had fallen in and around Kansas City, Mo., before the snow tapered off before midday. Mayor Sly James declared a state of emergency as the city dealt with its second major snowstorm in less than a week.

Flights in and out of Kansas City International Airport began to resume Tuesday morning after many were canceled at the height of the storm, airport spokesman Joe McBride said. For a second straight week, school kids, government workers and others caught a break as most offices and buildings were closed across the region.

Area hospitals closed outpatient and urgent care centers, and the University of Missouri canceled classes for Tuesday. The Missouri Department of Transportation issued a "no travel" advisory, asking people to stay off affected highways except in case of a dire emergency. Even some of the state's own heavy-duty snow plows slid off into ditches, underlining the danger to others who were tempted to venture out.

Just west of Kansas City's Country Club Plaza in a neighborhood of aging apartment complexes, Matthew Meier found a large tree had uprooted and fallen onto the back of his 2002 Lincoln Town Car.

"I was completely sure I would find the tree trunk across the engine compartment," said Meier, 56. "But when I came outside I said, 'This doesn't look too bad at all.'"

In rural Kansas, blowing, wet snow forced truckers off the road and many had no idea when they would be able to get going again. Robert Branscecum, a trucker from Campton, Ill., hauling Wal-Mart merchandise to Dallas, had been stuck at Beto Junction near Lebo since Monday evening.

"It's hell, it's straight hell. It's snowing, blowing, drifting, everything," Branscecum said. "The cars are stuck in the parking lot. Some of the trucks that tried to leave got stuck. I'm not leaving anytime soon."

A strong low pressure system fueled the storm, which also deluged eastern Oklahoma and Texas with heavy rain and thunderstorms.

The storm knocked power out to tens of thousands of homes in Texas and Oklahoma and was blamed for the death of a two people killed in rollovers on Interstate 70 in Kansas Monday.

"We urge everyone to avoid travel and be extremely cautious if you must be on the roads," said Col. Ernest Garcia, superintendent of the Kansas Highway Patrol.

In Oklahoma, a person was killed after 15 inches of snow brought down part of a roof in the northwest town of Woodward. Heavy snow caused roofs to cave in at businesses in Belton and Warrensburg, Mo., where 13 inches of snow fell, police said.

Whiteout conditions made all roads impassable for a while on Monday in the Texas Panhandle, said Paul Braun, a spokesman for the Texas Department of Transportation. A hurricane-force gust of 75 mph was recorded at the Amarillo, Texas, airport. The city saw the biggest snowfall total in Texas with 17 inches.

Schools and major highways in the Texas Panhandle remained closed for a second day Tuesday. Interstate 27 reopened between snow-hammered Amarillo and Lubbock, about 120 miles to the south, but units with the Texas National Guard were still working to clear Interstate 40 from the Oklahoma border to the New Mexico state line. The interstate is open within Amarillo's city limits.

The second major storm in as many weeks sent locals scurrying for their shovels, frustrated and annoyed that one huge blizzard could so closely follow another.

Climate scientists can't say that man-made global warming is the cause of such individual extreme weather events, but they say that climate change in general makes them more likely because of what it does to the thermodynamics of the air and water. Warmer air in general holds more moisture and when temperatures dance around the freezing mark ? cold enough to fall as snow, but warm enough to hold lots of moisture ? the storms dump more snow, especially if part of the storm system has been over unusually warm ocean water.

Since 1960, much of the United States has had twice as many extreme snowstorms as it had in the 60 years before, according to a new study by top scientists that will soon appear in the Bulletin of the American Meteorological Society. But global warming is also shortening the snow season, dramatically reducing spring snow in the Northern Hemisphere, the Global Snow Lab at Rutgers University found.

"These storms didn't just occur in a vacuum. They are fueled by record amounts of moisture in the atmosphere," Pennsylvania State University climate scientist Michael Mann said in an email Tuesday. "What is happening is that these storms are feeding on unusually warm oceans, including the 'noreaster 'Nemo' which fed off record warm sea surface temperatures off the U.S. East Coast, and the Midwestern storm now brewing, which is feeding on very warm Gulf of Mexico ocean surface temperatures."

Mann said the unusual warmth and moisture combine with cold air dipping down from the Arctic to produce heavy snow. He said some computer weather models predict the Midwestern storm may break a record for low-pressure, which is how meteorologists measure the strength of a storm.

The back-to-back storms have raised hopes that the moisture might ease the drought conditions that have gripped the Midwest for more than a year. The snowpack now resting on the plains will help, but it's no drought-buster, experts say.

"If we get one more storm like this with widespread 2 inches of moisture, we will continue to chip away at the drought, but to claim the drought is over or ending is way too premature," said meteorologist Mike Umscheid of the National Weather Service office in Dodge City, Kan.

___

Associated Press writers Betsy Blaney in Lubbock, Texas, Nomaan Merchant in Dallas, Jill Zeman Bleed and Kelly P. Kissel in Little Rock, Ark., Daniel Holtmeyer in Oklahoma City, Steve Paulson in Denver, Paul Davenport in Albuquerque, N.M., and Roxana Hegeman in Wichita, Kan., contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-02-26-Winter%20Storm/id-b97817f64f5843ec9a262883779d3951

Adam Lanza fox news obama cnbc dexter dexter ny times

Tech leaders plan virtual push on immigration

WASHINGTON (AP) ? High-tech leaders including the former heads of AOL and Mozilla are organizing a "virtual march for immigration reform" aimed at pressuring lawmakers to enact sweeping changes to the nation's immigration laws.

The effort unveiled Monday is particularly focused on making it easier for the U.S. to attract highly educated immigrants and those aiming to work in high-tech fields.

Silicon Valley leaders and others have long complained of the difficulties of bringing high-tech workers to the U.S., and immigration legislation taking shape on Capitol Hill is expected to address the issue.

The new effort, devised in part by New York Mayor Michael Bloomberg, aims to collect supporters and organize a time this spring for them to flood lawmakers' offices via Twitter, Facebook, by phone and in person.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-02-25-Immigration-Virtual%20March/id-98a56a2599bb447cb5cd1528193feaa8

christina aguilera Mayan End Of The World Olivia Black the voice World Ending 2012 gossip girl Ink Master

Voters head to polls in ex-Rep. Jackson's district

FILE - In the Dec. 15, 2012, Illinois Democratic U.S. Congressional hopeful Debbie Halvorson speaks during a candidate presentation at the 2nd Congressional District slating meeting in South Holland, Ill. Candidates for former Congressman Jesse Jackson Jr.'s 2nd congressional seat made their final push for votes Monday Feb. 25, 2013, ahead of tomorrow's high-stakes primary. Turnout is expected to be paltry despite the lurid headlines surrounding the disgraced Chicago Democrat and millions in outside super PAC money driven largely by the guns debate. (AP Photo/John Smierciak, File)

FILE - In the Dec. 15, 2012, Illinois Democratic U.S. Congressional hopeful Debbie Halvorson speaks during a candidate presentation at the 2nd Congressional District slating meeting in South Holland, Ill. Candidates for former Congressman Jesse Jackson Jr.'s 2nd congressional seat made their final push for votes Monday Feb. 25, 2013, ahead of tomorrow's high-stakes primary. Turnout is expected to be paltry despite the lurid headlines surrounding the disgraced Chicago Democrat and millions in outside super PAC money driven largely by the guns debate. (AP Photo/John Smierciak, File)

FILE - In this Dec. 15, 2012 file photo, Illinois Democratic U.S. Congressional hopeful Robin Kelly speaks during a candidate presentation at the 2nd Congressional District Slating Meeting in South Holland, Ill. Candidates for former Congressman Jesse Jackson Jr.'s 2nd congressional seat made their final push for votes Monday Feb. 25, 2013, ahead of tomorrow's high-stakes primary. Turnout is expected to be paltry despite the lurid headlines surrounding the disgraced Chicago Democrat and millions in outside super PAC money driven largely by the guns debate. (AP Photo/John Smierciak, File)

FILE - In this Feb. 7, 2013 file photo, Illinois Democratic U.S. Congressional hopeful Anthony Beale, speaks at a news conference in Chicago. Candidates for former Congressman Jesse Jackson Jr.'s 2nd congressional seat made their final push for votes Monday Feb. 25, 2013, ahead of tomorrow's high-stakes primary. Turnout is expected to be paltry despite the lurid headlines surrounding the disgraced Chicago Democrat and millions in outside super PAC money driven largely by the guns debate. (AP Photo/M. Spencer Green, File)

CHICAGO (AP) ? The primary contest to replace disgraced former U.S. Rep. Jesse Jackson was in the hands of Chicago-area voters Tuesday, just three months after his resignation and an intense period of campaigning by more than a dozen candidates.

The front-runners ? former state Rep. Robin Kelly, former U.S. Rep. Debbie Halvorson and Chicago Alderman Anthony Beale ? planned Election Day stops at train stations and restaurants in the district that spans Chicago's South Side, south suburbs and some rural areas. They were among 14 Democrats and four Republicans in the special primary, but the Democratic winner was expected to sail through the April 9 general election because of the heavily-Democratic region.

Beale planned to vote at a school in Chicago, Halvorson was set to cast a ballot at a suburban community center and Kelly voted early.

Voters haven't seen an open primary since 1995, when Jackson first won office.

Turnout at the polls was expected to be low, and candidates and election officials braced for a possible winter storm that could dump up to six inches of snow on the region and complicate Tuesday's logistics. Election officials said they were in communication with streets and sanitation workers about making sure pathways to polls were kept clear.

In Chicago, fewer than 2,800 voters, or roughly 2 percent or registered voters in the district, cast early ballots. In suburban Cook County ? the bulk of the district's voting population ? it was nearly 2 percent. The last time the Chicago area had a special primary election for Congress was 2009 after Rahm Emanuel left his seat to take a job as White House chief of staff. Roughly 18 percent of registered voters in the district spanning North Side neighborhoods voted. In suburban Cook County, the percentage was far lower.

Guns and ethics were on the minds of voters, and both were main issues on the campaign trail, particularly as Jackson's legal saga played out in federal court. He pleaded guilty to illegally spending $750,000 in campaign money on personal items and faces prison time. The son of the civil rights leader is the third consecutive congressman from the district to leave office under an ethical or legal cloud.

Still, gun control became the top issue on the campaign trail, including at candidate forums and television ads.

Independence USA, the super PAC of New York City Mayor Michael Bloomberg, poured more than $2 million into the race for anti-gun ads in support of Kelly and against Halvorson, a former state lawmaker and one-term congresswoman. Kelly supports a ban, but Halvorson does not.

"Gun control, we need it," said retiree Angela Craig, an undecided Chicago voter. She had supported Jackson in the past but didn't feel like she got enough time to weigh the candidates.

Jackson resigned in November after a months-long medical leave. He pleaded guilty early this month to charges that he misspent $750,000 in campaign money on lavish personal items, including a Rolex watch and furs. His departure created a rare opening in the district.

__

Sophia Tareen can be reached at http://twitter.com/sophiatareen

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-02-26-House-Jackson%20Seat/id-6604acf8d2ee4c339376a329912eae90

cyber monday deals small business saturday small business saturday best cyber monday deals best cyber monday deals macaulay culkin Larry Hagman

A Baby Monitor App Captured the Adorable Truth of What Happens When a Toddler Is Trying to Sleep

Say it with me now: Hahahawwwwwhahah. This awesome toddler is named Jude and this video shows what he's actually doing when his parents shut off the lights and try to make him sleep. It's punishingly adorable. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/8Bki0zYrYkw/a-baby-monitor-app-captured-the-adorable-truth-of-what-happens-when-a-toddler-is-trying-to-sleep

paula abdul cinnamon challenge lou dobbs rock salt david letterman march of dimes james randi

'NanoVelcro' device to grab single cancer cells from blood: Improvement enables 'liquid biopsies' for metastatic melanoma

Feb. 22, 2013 ? Researchers at UCLA report that they have refined a method they previously developed for capturing and analyzing cancer cells that break away from patients' tumors and circulate in the blood. With the improvements to their device, which uses a Velcro-like nanoscale technology, they can now detect and isolate single cancer cells from patient blood samples for analysis.

Circulating tumor cells, or CTCs, play a crucial role in cancer metastasis, spreading from tumors to other parts of the body, where they form new tumors. When these cells are isolated from the blood early on, they can provide doctors with critical information about the type of cancer a patient has, the characteristics of the individual cancer and the potential progression of the disease. Doctors can also tell from these cells how to tailor a personalized treatment to a specific patient.

In recent years, a UCLA research team led by Hsian-Rong Tseng, an associate professor of molecular and medical pharmacology at the Crump Institute for Molecular Imaging and a member of both the California NanoSystems Institute at UCLA and UCLA's Jonsson Comprehensive Cancer Center, has developed a "NanoVelcro" chip. When blood is passed through the chip, extremely small "hairs" -- nanoscale wires or fibers coated with protein antibodies that match proteins on the surface of cancer cells -- act like Velcro, traping CTCs and isolating them for analysis.

CTCs trapped by the chip also act as a "liquid biopsy" of the tumor, providing convenient access to tumor cells and earlier information about potentially fatal metastases.

Histopathology -- the study of the microscopic structure of biopsy samples -- is currently considered the gold standard for determining tumor status, but in the early stages of metastasis, it is often difficult to identify a biopsy site. By being able to extract viable CTCs from the blood with the NanoVelcro chip, however, doctors can perform a detailed analysis of the cancer type and the various genetic characteristics of a patient's specific cancer.

Improving the NanoVelcro device

Tseng's team now reports that they have improved the NanoVelcro chip by replacing its original non-transparent silicon nanowire substrate inside with a new type of transparent polymer nanofiber-deposited substrate, allowing the device's nanowires to better "grab" cancer cells as blood passes by them.

Tseng and his colleagues were able to pick single CTCs immobilized on the new transparent substrate by using a miniaturized laser beam knife, a technique called laser micro-dissection, or LMD.

The researchers' paper on their improvement to the chip was published online Feb. 22 in the peer-reviewed journal Angewandte Chemie and is featured on the cover of the journal's March 2013 print issue.

"This paper summarizes a major milestone in the continuous development of NanoVelcro assays pioneered by our research group," Tseng said. "We now can not only capture cancer cells from blood with high efficiency but also hand-pick single CTCs for in-depth characterization to provide crucial information that helps doctors make better decisions."

Testing the improvements on melanoma

Using the new assay on patients' blood containing circulating melanoma cells (CMCs), Tseng's team was able to isolate and preserve single CMCs. Melanoma is a deadly type of skin cancer that is prone to spreading quickly throughout the body. The ability to capture and preserve single CMCs allows doctors to analyze melanoma cells' DNA structure, determine the genetic characteristics of the patient's cancer and confirm that the circulating cells remain genetically similar to the tumor they came from.

The preservation of single captured CMCs in this proof-of-concept study also allowed researchers to conduct an analysis -- called single-cell genotyping -- to find within the cell a specific target (BRAF V600E) for a drug called vemurafenib. BRAF V600E is a mutation in the BRAF protein that appears in approximately 60 percent of melanoma cases. Drugs that inhibit BRAF are able to slow and often reverse the growth of melanoma tumors.

"With this technology, we are getting closer to the goal of a widely clinically applicable liquid biopsy, where we can sample cancer cells by a simple blood draw and understand the genes that allow them to grow," said Dr. Antoni Ribas, a professor of medicine in the division of hematology-oncology, a Jonsson Cancer Center member and one of Tseng's key collaborators. "With the NanoVelcro chips, we will be able to better personalize treatments to patients by giving the right treatment to stop what makes that particular cancer grow."

Dr. Roger Lo, another key Tseng collaborator and an assistant professor in UCLA's department of medicine, division of dermatology, and department of molecular and medical pharmacology, was also optimistic about the new method.

"This scientific advancement -- being able to capture the melanoma cells in transit in the blood and then perform genetic analysis on them -- will in principle allow us to track the genomic evolution of melanoma under BRAF-inhibitor therapy and understand better the development of drug resistance," said Lo, who is also a member of the Jonsson Cancer Center.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

---

Story Source:

The above story is reprinted from materials provided by University of California - Los Angeles. The original article was written by Shaun Mason.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Shuang Hou, Libo Zhao, Qinglin Shen, Juehua Yu, Charles Ng, Xiangju Kong, Dongxia Wu, Min Song, Xiaohong Shi, Xiaochun Xu, Wei-Han OuYang, Rongxian He, Xing-Zhong Zhao, Tom Lee, F. Charles Brunicardi, Mitch Andr? Garcia, Antoni Ribas, Roger S. Lo, Hsian-Rong Tseng. Polymer Nanofiber-Embedded Microchips for Detection, Isolation, and Molecular Analysis of Single Circulating Melanoma Cells. Angewandte Chemie International Edition, 2012; DOI: 10.1002/anie.201208452

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/biochemistry/~3/0FRgHxcuhiQ/130225092252.htm

ed reed football schedule jo paterno dead south carolina tuskegee airmen mike james red tails

Hertz forecasts strong 2013 as pricing improves

(Reuters) - Hertz Global Holdings Inc reported a quarterly loss due to costs related to its acquisition of Dollar Thrifty, but adjusted profit beat analysts' expectations and the car rental company forecast strong results for 2013 on higher pricing.

Hertz forecast adjusted earnings of $1.82 to $1.92 per share for 2013 on revenue of $10.85 billion to $10.95 billion.

Analysts on average expect earnings of $1.78 per share on revenue of $10.79 billion, according to Thomson Reuters I/B/E/S.

Hertz is off to a "fast start" for the year, Chief Executive Mark Frissora said in a statement.

Car rental revenue per transaction day at U.S. airports rose 6 percent for Hertz and 2.6 percent for Dollar Thrifty in January, Frissora said.

This compares with a 1.6 percent increase for Hertz in December and 4.6 percent for Dollar Thrifty.

The car rental industry, tied closely to airline traffic and hotel bookings, has benefited from recovering business and travel in the United States.

Pricing in the U.S. commercial business, which serves corporate customers at airports, has been under pressure in recent quarters as the major players try to attract more customers by offering lower prices.

To diversify away from airport rentals, Hertz fought a long battle with rival Avis Budget Group Inc over Dollar Thrifty, which serves the leisure car rental market.

After more than two years of first making a public offer, Hertz acquired Dollar Thrifty for $2.6 billion in late 2012 after agreeing to give up 29 Dollar Thrifty airport locations and sell its low-cost Advantage brand.

The acquisition is expected to save the merged company at least $160 million annually and cement Hertz's No. 2 position in the global car rental rankings behind privately held Enterprise Holdings.

Synergies from the acquisition are likely to exceed earlier forecasts, Hertz said on Monday.

Hertz's net loss was $36.4 million, or 9 cents per share, in the fourth quarter, compared with net income of $52.1 million, or 11 cents per share, a year earlier.

Excluding items, Hertz earned 33 cents per share.

Revenue rose 15 percent to $2.3 billion.

Analysts expected earnings of 31 cents per share on revenue of $2.27 billion.

Park Ridge, New Jersey-based Hertz's shares have gained nearly 50 percent since announcing the Dollar Thrifty acquisition in August 2012. The stock closed at $18.73 on Friday on the New York Stock Exchange.

(Reporting by A. Ananthalakshmi in Bangalore; Editing by Supriya Kurane and Roshni Menon)

Source: http://news.yahoo.com/hertz-posts-quarterly-loss-dollar-thrifty-buy-111207475--sector.html

Wimbledon 2012 TV Schedule fourth of july Jason Terry IFE Fireworks 2012 4th Of July independence day BET Awards 2012

Chipper comfortable as 'rookie coach'

Sorry, Readability was unable to parse this page for content.

Source: http://mlb.mlb.com/news/article.jsp?ymd=20130217&content_id=41739678&notebook_id=41739684&vkey=notebook_atl&c_id=atl

seattle times walker recall censor pipa and sopa sopa pipa wikipedia blackout kyla pratt

FIU baseball outruns Stony Brook to complete season-opening series sweep

By DAVID J. NEAL The Miami Herald

A hot pitching duel on a chilly day at FIU Baseball Stadium was decided by baserunning. FIU knew when to go. Stony Brook didn?t know when to stop.

So FIU got the run it needed for a three-game series sweep of a 2012 College World Series participant, and Stony Brook left with a fading memory of what home plate looked like from the scoring side.

After the Sea Wolves scored four runs in the first four innings of the first game, FIU zeroed them out over the series? last 23 innings.

?A lot of that, yes, is our pitching staff, but also them coming from up north,? FIU coach Turtle Thomas said. ?It snowed three feet a week ago. You?ve got to get out and get your game at-bats. Like us. That?s why the game ended in about 2 hours 35 minutes [actually 2:33] because neither one of us hit the ball [Sunday].?

Combining for the shutout were junior starter Mike Franco, working on a 45-pitch count while being 10 months removed from Tommy John surgery; Alex Seibold, a freshman from Plantation American Heritage; junior Mitchell Davis, reprising his two innings of middle relief from Saturday?s second game; and senior closer Michael Gomez, who took care of the ninth again.

Franco got the win. In acknowledgement of his remarkable progress in recovering, the entire team left the dugout to greet Franco after his 2?2/3 innings, during which he allowed one hit, struck out four and got his fastball up to 94 mph.

?Everything was coming together little by little,? Franco said. ?I can honestly say I felt better this first game than I have [in] the intrasquad games. So that?s a good sign.?

FIU scored the only run of the game in the first innnig. Sophomore Julius Gaines ? who was 3 for 4 Sunday and 7 for 10 in the series ? singled and went to third on Nathan Burns? single. Josh Anderson?s blooper to right brought Gaines in for the winning run.

The closest Stony Brook came to tying produced a moment as comical as it was critical.

With two out in the fourth and Stony Brook?s Cole Peragine on first, Steven Goldstein ripped a drive inside the first base line and into the right field corner outside the foul line. Peragine rounded third and looked to be an 85-foot sprint from tying the game, but got held up by the third base coach as Burns retrieved the ball. Goldstein, obviously expecting Peragine to be sent home, continued steaming toward third.

Suddenly, there were too many Sea Wolves around third as the ball arrived. Peragine tried to make a belated break for the plate only to be tagged out by Anderson. Anderson actually missed the tag the first time, realized his error after he and Peragine had slowed, then tagged Peragine out.

Source: http://www.miamiherald.com/2013/02/18/3240371/fiu-baseball-outruns-stony-brook.html

act Black Ops 2 Secede ben roethlisberger Diwali elmo Kevin Clash

'Great Gatsby' Wedding Inspiration From Vera Wang (PHOTOS)

Ahh, "The Great Gatsby." Whatever your feelings on the canonical work, "Gatsby" is making a return to the spotlight -- in film form. While it won't make its silver screen debut until May 10, anticipation is already building. And nowhere is the excitement greater than in the world of weddings.

With costumes by Prada, every fashionista bride will be looking to the film for vintage wedding inspiration. WHITE by Vera Wang has some gorgeous vintage-inspired options. Click through the slideshow below to see some of our favorites!

• Soft v-neck gown with hand-appliqued lace. Available at <a href="http://www.davidsbridal.com">David's Bridal</a>, $800.

• Crinkle chiffon column gown with sheer straps. Available at <a href="http://www.davidsbridal.com">David's Bridal</a>, $628.

• Georgette mermaid gown with organza skirt. Available at <a href="http://www.davidsbridal.com">David's Bridal</a>, $1,498.

• Crinkle chiffon fit-and-flare gown. Available at <a href="http://www.davidsbridal.com">David's Bridal</a>, $728.

• Crystal feather hair comb with antique setting. Available at <a href="http://www.davidsbridal.com">David's Bridal</a>, $128.

• Crystal orchid clip. Available at <a href="http://www.davidsbridal.com">David's Bridal</a>, $98.

• Crystal bow clip with feather spray. Available at <a href="http://www.davidsbridal.com">David's Bridal</a>, $128.

• BLACK by Vera Wang wool tuxedo. Available at <a href="http://www.menswearhouse.com/verawang">Men's Wearhouse</a>.

• BLACK by Vera Wang wool tuxedo. Available at <a href="http://www.menswearhouse.com/verawang">Men's Wearhouse</a>.

Keep in touch! Check out HuffPost Weddings on Facebook, Twitter and Pinterest.

"; var coords = [-5, -72]; // display fb-bubble FloatingPrompt.embed(this, html, undefined, 'top', {fp_intersects:1, timeout_remove:2000,ignore_arrow: true, width:236, add_xy:coords, class_name: 'clear-overlay'}); });

Source: http://www.huffingtonpost.com/2013/02/18/great-gatsby-wedding-insp_n_2681797.html

aj jenkins shea mcclellin nfl draft 2012 whitney mercilus 2012 nfl draft picks andrew luck andrew luck

Stocks rise as S&P 500 extends streak

Stocks closed higher on Wall Street Friday with the Standard & Poor's 500 ending the week nearly two points higher.?Investors have piled into stocks at the beginning of the year after lawmakers reached a last-minute deal to avoid the "fiscal cliff."

By Steve Rothwell,?AP Business Writer / February 15, 2013

Traders work on the floor of the New York Stock Exchange, Friday. Despite recent gains in stocks, there are signs that the rally is running out of steam.

Brendan McDermid/Reuters

Enlarge

The S&P 500 kept its winning streak alive.

Skip to next paragraph

' + google_ads[0].line2 + '
' + google_ads[0].line3 + '

'; } else if (google_ads.length > 1) { ad_unit += ''; } } document.getElementById("ad_unit").innerHTML += ad_unit; google_adnum += google_ads.length; return; } var google_adnum = 0; google_ad_client = "pub-6743622525202572"; google_ad_output = 'js'; google_max_num_ads = '1'; google_feedback = "on"; google_ad_type = "text"; google_adtest = "on"; google_image_size = '230x105'; google_skip = '0'; // -->

Subscribe Today to the Monitor

Click Here for your FREE 30 DAYS of
The Christian Science Monitor
Weekly Digital Edition

The Standard & Poor's 500 ended the week nearly two points higher, enough to give it a seventh straight week of gains. That's the longest stretch of advances in more than two years.

The index lost 1.59 points to end at 1,519.79 Friday. For the week it held on to a gain of 1.86 points.

Investors piled into stocks at the beginning of the year after lawmakers reached a last-minute deal to avoid the "fiscal cliff" of sweeping tax hikes and spending cuts. The gains continued as investors were encouraged by signs that the housing and jobs markets are recovering. Company earnings have also held up well.

There are signs, however, that the rally is running out of steam.

The Dow Jones industrial average rose 8.37 points to close at 13,981.76 Friday, but ended the week down 11 points. The index has now edged lower for two straight weeks.

"We've just had such a fast start to the year," said John Fox, manager of the FAM value fund. "It just makes sense that you are going to have a leveling or a slowdown."

Walmart was the biggest decliner in the Dow Friday. The stock fell $1.52, or 2.2 percent, to $69.30 after Bloomberg News published excerpts from an internal e-mail that said sales in February were a "total disaster." The retailer, which reports earnings next week, said that sometimes internal communications lacked "proper context" and "are not entirely accurate."

Energy companies also contributed to the slump, following the price of crude oil lower. Chevron dropped 75 cents, or 0.6 percent, to $114.96.

The Nasdaq composite fell 6.63 points to 3,192.03 and was also down for the week, dropping 1.84 points.

Herbalife gained 47 cents, or 1.2 percent, to $38.74, and climbed as high as $44.93 after the billionaire investor Carl Icahn disclosed that he had accumulated a 13 percent stake in the company. The stock of the dietary supplement maker slumped last year after Pershing Square Capital Management's William Ackman described it as a massive pyramid scheme and placed bets that it would fall.

Investors are continuing to put money into stocks. Lipper, a unit of financial data provider Thomson Reuters, reported that $2.4 billion flowed into stock funds this week, marking the sixth straight week of increases. In January $37.4 billion went into stock funds, the most in that month since 2000.

The yield on the 10-year Treasury note, which moves inversely to its price, has risen as investors have put more cash into stocks. The yield rose 1 basis point to 2.01 percent, having started the year at 1.70 percent.

Among other stocks making big moves:

? MeadWestvaco, a packaging company, surged $3.97, or 12.5 percent, to $35.65 after Nelson Peltz's Trian Fund Management disclosed that it had taken a $51 million stake in the company.

? Xoom, an online money transfer company, surged $9.49, or 59 percent, to $25.49 on its first day as a publicly traded company. Xoom raised $101.2 million from selling 6.3 million shares at $16 each.

? Burger King gained 78 cents, or 4.7 percent, to $17.36. The company's fourth-quarter earnings nearly doubled after it revamped its menu.

? St. Jude Medical fell $1.48, or 3.4 percent, to $41.53 after a Cowen & Co. analyst downgraded the medical device maker's stock, saying he believes the company's Durata heart wire is not very different from older wires that have been taken off the market.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/07oRdpIHt5g/Stocks-rise-as-S-P-500-extends-streak

brandon weeden felicia day nfl 2012 draft st louis rams miami dolphins buffalo bills pittsburgh steelers

Adventurers re-enact one of the greatest survival stories of all-time

WELLINGTON, New Zealand (AP) ? It's been lauded as one of the greatest survival stories of all-time.

Nearly 100 years later, a group of British and Australian adventurers have discovered why. They re-enacted Ernest Shackleton's journey to save his crew when their ship got stuck and sank in Antarctica's icy waters.

Tim Jarvis and Barry "Baz" Gray reached an old whaling station on remote South Georgia island Monday, 19 days after leaving Elephant Island. Just as Shackleton did in 1916, Jarvis and his team sailed 800 nautical miles (1,300 kilometers) across the Southern Ocean in a small lifeboat and then climbed over crevasse-filled mountains in South Georgia.

The modern-day team of six used similar equipment and clothes. But the harsh conditions forced several of them to abandon their attempt along the way.

"It was epic, really epic, and we've arrived here against the odds," Jarvis told his project manager Kim McKay after reaching the station, adding that "we had more than 20 crevasse falls up to our knees and Baz fell into a crevasse up to his armpits."

McKay said Jarvis was suffering frostbite in his right foot after the journey. He planned Tuesday to hike to the grave site of Shackleton, who was buried on the island years after his journey.

Jarvis wasn't the only one suffering foot problems. Three of the men couldn't complete the climb after suffering the ailment trench foot, caused by prolonged exposure to cold and wet conditions.

"The boat was only 22? feet (6.8 meters) long. At any one time, only four men could be below deck, while the other two had to be on deck. They had 8-meter (26-foot) waves crashing onto the boat," McKay said. "It was like they were playing a game of twister. If one moved, they all had to move. They were constantly wet and cold and they all arrived with varying degrees of trench foot."

Shackleton completed the climb without a tent. Jarvis and his team were planning to do the same but were forced to use modern-day tents and sleeping bags when a blizzard hit. One member of the team turned back and then later rejoined Jarvis and Gray with more provisions and wearing modern-day clothing.

Shackleton's survival story was remarkable in that the final two legs of his journey came after the 28 crew had endured more than a year in Antarctica. Their ship "Endurance" was trapped and then crushed by the ice pack and the men later sailed in lifeboats to Elephant Island, where 22 of them stayed, waiting for help. After reaching the whaling station, Shackleton was able to raise the alarm and save all his crew.

While Jarvis, who lives in Australia and also has British citizenship, and his team tried to recreate many of the conditions, there were limits ? they decided to eat salami rather than the penguins and seals on which Shackleton's crew subsisted.

"These early explorers were iron men in wooden boats," Jarvis told McKay, adding that he hoped "we've been able to emulate some of what they achieved."

___

Follow Nick Perry on Twitter at http://twitter.com/nickgbperry

Source: http://news.yahoo.com/adventurers-enact-shackletons-antarctic-voyage-053847427.html

pollen count mexico city first day of spring mexico earthquake aziz ansari aziz ansari katherine jenkins